周非凡（博士），教授、博士生導師，獲全國百篇優秀博士學位論文，國家海外高層次人才青年項目，海南省第十屆青年科技獎，當選SPIE FELLOW。2010-2013 華南師範大學 曆任助理研究員、副研究員；2014-2018 美國俄克拉荷馬中央大學 曆任研究助理、研究助理教授、研究副教授；2018-2020深圳大學 特聘教授；2020 海南大學 教授。
主要研究方向：
1) 腫瘤光學精準診療技術研發；
發展了微創光療聯合免疫治療這一藥械協同治療模式，研究并闡明了激光腫瘤治療的抗腫瘤免疫新機制，開發了切實有效的激光免疫聯合療法成功治療晚期黑色素瘤病人，極大地推動了新型腫瘤治療模式的發展及臨床應用，該療法已于2023年6月被美國FDA批準用于肺癌等臨床研究。
2) 神經免疫可視化及調控研究。
開發腦膜淋巴管活體光學成像監測技術與系統，實現腦膜淋巴管微環境高分辨、大視野、實時動态監測。提出通過調控腦膜淋巴管引流促進腦内代謝廢物清除，從而改善衰老及神經退行性疾病認知功能的無創光療神經調控技術，有望為神經退行性疾病治療提供高效無損的非藥物幹預手段。
學術論文：
在Nature Communication、Brain Behavior and Immunity、Nano Letter、 Clinical Cancer Research等國際知名學術期刊發表SCI論文50餘篇，被引5000餘次；入選2022、2023年度全球2 %高被引科學家。
文章詳見：https://scholar.google.com/citations?user=aIzZwnwAAAAJ&hl=en
代表性論文：
1. Wang M, Yan C, Li X, Yang T, Wu S, Liu Q, Luo Q*, Zhou F*. Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer’s disease-associated pathology and cognition in mice. Nature Communications (2024) 15:1453. (綜合性期刊1區)
2. Rao J, Sun W, Wang X, Li J, Zhang Z, Zhou F*. A novel role for astrocytic fragmented mitochondria in regulating morphine addiction, Brain Behav. Immun. 2023, 113, 328-339. (神經科學1區)
3. Wang M#, Yan D#, Wang M, Wu Q, Song R, Huang Y, Rao J, Wang D*, Zhou F*, Tang BZ*. A versatile 980 nm absorbing aggregation-induced emission luminogen for NIR-II imaging-guided synergistic photo-immunotherapy against advanced pancreatic cancer, Adv. Funct. Mater.2022, 2205371. (工程技術1區)
4. Wang M, Li Y, Wang M, Liu K, Hoover AR, Li M, Towner RA, Mukherjee P, Zhou F*, Qu J*, Chen WR*. Synergistic Interventional Photothermal Therapy and Immunotherapy Using an Iron Oxide Nanoplatform for the Treatment of Pancreatic Cancer, Acta Biomaterialia, 2022, 138(15): 453-462.(工程技術1區) 入選高被引論文
5. Wang M, Rao J, Wang M, Li X*, Liu K, Naylor M F, Nordquist R E, Chen W R*, Zhou F*. Cancer photo-immunotherapy: from bench to bedside. Theranostics 2021, 11 (5), 2218-2231. (醫學1區) 入選高被引論文
主持科研項目：
1. 科技創新2030-“腦科學與類腦智能”重大項目青年項目，針對腦膜淋巴管微環境實時檢測和調控的活體多模态光學關鍵技術與系統研究，2022.08-2026.07，500萬，在研；
2. 國自然面上項目，基于腫瘤微環境活體影像評價光免疫協同治療及其機制研究2022.01-2025.12，55萬，在研；
3. 海南省科技人才創新項目，改善老年神經認知功能的無損光學調控及監控技術研發，2024.01-2025.12，100萬，在研；
4. 萬甯市中信局橫向項目，槟榔神經影響比對研究，2022.05-2025.04，300萬，在研；
5. 海南省重點研發項目，影像引導的前列腺癌激光免疫精準治療技術研發，2021.09-2023.09，40萬，結題；
6. 國自然海外青年英才基金，2019.01-2022.12，200萬，結題；
7. 廣東省科技廳重點研發項目，基于光聲成像的鼻咽癌激光免疫精準診療技術研究，2019.01-2022.12，300萬，結題。
獲獎與榮譽稱号：
2013 FEBS J 學術期刊高引用獎;
2013 教育部科學技術獎二等獎 (骨幹);
2014 全國百篇優秀博士學位論文；
2017 國家海外高層次人才青年項目入選者；
2022 海南省優秀研究生導師；
2023 海南省青年科技獎；
2024 SPIE Fellow
學術兼職：
國際光學工程學會（SPIE）Photonics West “Biophotonics and Immune Responses”會議的委員會共主席（Program Committee Chair），中國生物醫學工程學會生物醫學光子學分會委員，中國抗癌協會腫瘤精準治療分會委員，海南省生物醫學工程學會理事長。
招生需求：
招收神經生物學、腫瘤學、免疫學、光學、生物醫學工程及相關專業的碩士生、博士生、博士後和預聘教師。
郵箱：zhouff@hainanu.edu.cn
Feifan Zhou, PhD.
Professor, PhD supervisor
School of Biomedical Engineering
Hainan University, Haikou, China
Email: zhouff@hainanu.edu.cn
Professor Feifan Zhou was the gainer of Excellent Doctoral Thesis Award of China and National Overseas High-level Talents Youth Program. She have published more than 50 peer-reviewed papers with more than 3000 citations. She also received several research grants, delivered several invited talks in international conferences, and served as members in many academic organizations.
Research Interests
Optical technology in tumor theranostics and neuroimmune regulation
Nanomaterials based theranostics for cancer and neurodegenerative diseases
Synergized phototherapy and immunotherapy for metastatic cancer
Education
09/2000-07/2004 Bioscience B.S. Henan University, China
09/2005-06/2010 Optics Ph.D. South China Normal University, China
Positions
07/2010-12/2011 Assistant Professor of Research, South China Normal University
01/2012-12/2013 Associate Professor of Research, South China Normal University
01/2014-09/2015 Research Associate, University of Central Oklahoma
10/2015-05/2017 Assistant Professor of Research, University of Central Oklahoma
06/2017-06/2018 Associate Professor of Research, University of Central Oklahoma
07/2018-07/2020 Professor, Shenzhen University
08/2020- present Professor, Hainan University
Awards
2017 High-level Youth Talents Program
2013 Excellent Doctoral Thesis Award of China
2012 Excellent Doctoral Thesis Award of Guangdong, China
2012 Ministry of Education Science and Technology Progress Award, China
2011 Academic Journal High Citation Award in 2011, FEBS J
Patents
A device and a method for imaging-guided photothermal laser therapy for cancer treatment, 2018 US9,987,089 B2, US Patent.
A hand-held intervention device and using method of hand-held intervention device, 201910369172.9, China Patent
Relevant Peer-Reviewed Publications
▶ Feifan Zhou#*, Meng Wang#, Teng Luo, Junle Qu*, Wei R. Chen*. Photo-activated chemo-immunotherapy for metastatic cancer using a synergistic graphene nanosystem. Biomaterials 2021; 265, 120421.
▶ Feifan Zhou#, Jingxuan Yang#, Yuqing Zhang, Mingyang Liu, Mark L Lang, Min Li*, Wei R Chen*, Local phototherapy synergizes with immunoadjuvant for treatment of pancreatic cancer through induced immunogenic tumor vaccine. Clinical Cancer Research 2018;24(21):5335-5346.
▶ Mark F. Naylor, Feifan Zhou*, Brian V. Geister, Robert E. Nordquist, Wei R. Chen, Treatment of advanced melanoma with laser immunotherapy and ipilimumab. J Biophotonics 2017, 10(5), 618-622.
▶ Feifan Zhou#, Xiaosong Li#, Mark F. Naylor, Tomas Hode, Robert E. Nordquist, Luciano Alleruzzo, Joseph Raker, Samuel S.K. Lam, Nan Du, Lei Shi, Xiuli Wang, Wei R. Chen*. InCVAX - A novel strategy for treatment of late-stage, metastatic cancers through photoimmunotherapy induced tumor-specific immunity. Cancer Lett. 2015, 395, 169-177.
▶ Feifan Zhou, Shengnan Wu, Sheng Song, Wei R. Chen, Daniel E. Resasco, Da Xing*, Antitumor immunologically modified carbon nanotubes for photothermal therapy. Biomaterials 2012, 33, 3235-3242.
▶ Sheng Song, Feifan Zhou*, Wei R. Chen, Low-level laser therapy regulates microglial function through Src-mediated signaling pathways: implications for neurodegenerative diseases, J Neuroinflam 9, 219, 2012.
▶ Feifan Zhou#, Shengnan Wu#, Yi Yuan, Wei R. Chen, Da Xing*, Mitochondria targeting photoacoustic therapy using single-walled carbon nanotubes. Small 2012, 8, 1543–1550.
▶ Feifan Zhou#, Shengnan Wu#, Baoyan Wu, Wei R. Chen, Da Xing*, Mitochondria-targeting single-walled carbon nanotubes for cancer photothermal therapy, Small 2011, 7, 2727–2735.
▶ Feifan Zhou, Da Xing*, Baoyan Wu, Shengnan Wu, Zhongmin Ou, Wei R. Chen, New insights of transmembranal mechanism and subcellular localization of non covalently modified single-walled carbon nanotubes, Nano Lett. 2010, 10, 1677-1681.
▶ Feifan Zhou, Da Xing, ZhongminOu, Baoyan Wu, Daniel E. Resasco, Wei R. Chen, Cancer photothermal therapy in the near-infrared region by using single-walled carbon nanotubes, J. Biomed. Opt. 14(2), 021009, 2009.
Research Support
▶ Key R&D Project of Guangdong Provincial, Photoacoustic guided photo-immunotherapy for nasopharyngeal carcinoma, 2019.01-2021.12, 3 million yuan.
▶ National Natural Science Foundation of China (Youth Talents Program) , Basic research on the application of photoimmunotherapy, 2020.01-2022.12, 2 million yuan.
▶ National Natural Science Foundation of China, Basic research on mitochondria targeting carbon nanotubes mediated cancer laser therapy, 2012.01-2014.12, 220 thousands yuan.
Academic Service
▶ Program committee member, Biophotonics and Immune Responses Branch, Photonics West of Society of Photo-Optical Instrumentation Engineers (SPIE)
▶ Committee member, Biomedical Photonics Branch, Chinese Society of Biomedical Engineering
▶ Youth committee member, Photodynamic Therapy Branch, Chinese Anti-Cancer Association
Current Opening
Opening for Master students/PhD students/Post-doctoral Fellows/Pre-employed teachers in biology, medicine, optics, biomedical engineering and other related areas.
