嶽峰 (M.D., Ph.D.), 365英国上市官网在线教授、博士研究生導師。首都醫科大學神經病學專業醫學博士、臨床醫學專業博士後。北京大學光華管理學院高級管理人員工商管理碩士。1994-2003年在新疆醫科大學第一附屬醫院神經内科從事臨床診療、教學與科研工作，曆任主治醫師，講師，副主任醫師，副教授。2008-2020年在首都醫科大學宣武醫院/北京市老年病醫療研究中心工作，曆任副主任醫師、副研究員、研究員。

長期從事神經系統疾病臨床診療、基礎與轉化醫學研究工作。參與建立了國内早期獲得aaalac國際資質認證的專業靈長類動物實驗室，負責實驗技術平台運營管理。探索實踐了基于人類疾病靈長類動物模型及其靈長類動物實驗平台的轉化醫學研究與新藥研發服務模式，拓展了多項與國内外新藥研發機構、生物技術公司以及大學、科研院所的研究合作。曾在美國威斯康星國家靈長類研究中心及制藥企業等機構學習培訓。

當前主要工作是開展中樞神經系統疾病的基礎與轉化醫學研究，以及基于非人靈長類模式動物的腦科學/轉化醫學研究條件支持平台的運行。

  研究方向： 

1）神經退行性疾病（阿爾茨海默病、帕金森氏病）發病學研究。應用系統性、多維尺度方法開展神經退行性疾病早期發病與演化機制的研究。

2）中樞神經系統疾病神經功能重建研究。基于神經系統疾病拟臨床靈長類動物模型以及微生理系統仿真模型，開展神經功能重建研究。

  課題、專利與獎項： 

主持國家重點研發計劃“幹細胞及轉化研究”重點專項課題，神經幹細胞在重大神經疾病猴模型中的臨床前評估”；“十二五”國家高技術研究發展計劃 (863計劃)“代謝類重大疾病靈長類模型的研發”課題以及國家自然科學基金面上項目。參與科技創新2030-“腦科學與類腦研究”重大項目”腦疾病模型猴制備與疾病早期診斷指标建立”課題。獲授權發明專利7項，已受理公開的發明專利、實用新型專利12項；獲省級科學技術獎2項。

  學術論文（*為通訊作者）： 

1.  Xinxin Huang, Shanshan Huang, Fangyan Fu, Junzhen Song, Yuling Zhang, Feng Yue*. Characterization of preclinical Alzheimer’s disease model: spontaneous type 2 diabetic cynomolgus monkeys with systemic pro-inflammation,positive biomarkers and developing AD-like pathology. Alzheimers Research & Therapy, 2024, 16(1):52.

2.  Jiajun Deng, Bin Liu, Qian Tao, Yanyu Luo, Yi Zhu, Xinxin Huang , Feng Yue*. The co-oligomers of Aβ42 and human islet amyloid polypeptide exacerbate neurotoxicity and Alzheimer-like pathology at cellular level. Neuroscience.2024,S0306-4522(24)00155-6

3.  Yu Bao, Chaoning Gan, Zuyue Chen, Zhongquan Qi, Zhiqiang Meng, Feng Yue*. Quantification of Non-Motor Symptoms in Parkinsonian Cynomolgus Monkeys. Brain Sciences.2023, 13(8), 1153.

4.  Tang L, Xu N, Huang M, Yi W, Sang X, Shao M, Li Y, Hao ZZ, Liu R, Shen Y, Yue F, Liu X, Xu C, Liu S. A primate nigrostriatal atlas of neuronal vulnerability and resilience in a model of Parkinson's disease. Nat Commun. 2023,14(1):7497.

5.  Fan Yang; Xueyan Jiang; Feng Yue; Luyao Wang; Henning Boecker; Ying Han; Jiehui Jiang. Exploring dynamic functional connectivity alterations in the preclinical stage of Alzheimer’s disease: an exploratory study from SILCODE, Journal of Neural Engineering, 2022, 19(1): 016036-016036

6.  Su Feng , Ting Zhang, Wei Ke , Yujie Xiao , Zhong Guo , Chunling Lu, Shuntang Li , Zhongxin Guo, Yuanyuan Liu , Guohe Tan , Yingying Chen , Feng Yue , Yousheng Shu, Chunmei Yue  and Naihe Jing .The long-term survival and functional maturation of human iNPC-derived neurons in the basal forebrain of cynomolgus monkeys. Life Medicine. 2022, 1(2):196–206.

7.  Feng Yue*, Su Feng, Chunling Lu, Ting Zhang, Guoxian Tao, Jing Liu, Chunmei Yue, Naihe Jing. Synthetic amyloid-β oligomers drive early pathological progression of Alzheimer’s disease in nonhuman primates. iScience 2021, 24(10), 103207.

8.  Jian-Jun Guo, Feng Yue, Dong-Yan Song, Luc Bousset, Xin Liang , Jing Tang, Lin Yuan, Wen Li, Ronald Melki, Yong Tang, Piu Chan, Chuang Guo, Jia-Yi Li. Intranasal administration of α-synuclein preformed fibrils triggers microglial iron deposition in the substantia nigra of Macaca fascicularis. Cell Death Dis. 2021,12(1):81.

9.  Yan Sun, Chuang Guo, Lin Yuan, Wen Li, Zhan-You Wang, Feng Yue*, Jia-Yi Li. Cynomolgus Monkeys with spontaneous Type-2-Diabetes-Mellitus-like pathology develop alpha-synuclein alterations reminiscent of prodromal Parkinson's Disease and related diseases. Front Neurosci. 2020, 14:63.

10.  Li S, Zhang H, Wang A, Liu Y, Liu H, Yue F, Abulaiti X, Zhang C, Li L. Differentiation of adult human retinal pigment epithelial cells into dopaminergic-like cells in vitro and in the recipient monkey brain. Mol Med. 2019 Mar 29;25(1):9.

11.  Song Zhang, Yilin Song, Mixia Wang, Guihua Xiao, Fei Gao, Ziyue Li, Guoxian Tao, Ping Zhuang, Feng Yue*, Piu Chan & Xinxia Cai.Real-time simultaneous recording of electrophysiological activities and dopamine overflow in the deep brain nuclei of a non-human primate with Parkinson’s disease using nano-based microelectrode arrays. Microsystems & Nanoengineering. 2018, 4, 17070.

12.  Li Z, Chen X, Wang T, Gao Y, Li F, Chen L, Xue J, He Y, Li Y, Guo W, Zheng W, Zhang L, Ye F, Ren X, Feng Y, Chan P, Chen JF. The Corticostriatal Adenosine A2A Receptor Controls Maintenance and Retrieval of Spatial Working Memory. Biol Psychiatry. 2018,83(6):530-541.

13.  Xu S, Zhang Y, Zhang S, Xiao G, Wang M, Song Y, Gao F, Li Z, Zhuang P, Chan P, Tao G, Yue F, Cai X. An integrated system for synchronous detection of neuron spikes and dopamine activities in the striatum of Parkinson monkey brain. J Neurosci Methods. 2018 Jul 1;304:83-91.

14.  Yue F, Zhang G Quintero JE, Gash DM, Zhang Z Role of social interaction, exercise, diet, and age on developing and untreated diabetes in cynomolgus monkeys. Exp Gerontol. 2017 Jun 15;96:82-88.

15.  Ren G, Yan J, Tao G, Gan Y, Li D, Yan X, Fu Y, Wang L, Wang W, Zhang Z, Feng Yue, Yang X. Rapid focal cooling attenuates cortical seizures in a primate epilepsy model. Exp Neurol. 2017 Sep;295:202-210.

16.  Yue F, Zeng S, Tang R, Tao G, Chan P. MPTP Induces Systemic Parkinsonism in Middle-Aged Cynomolgus Monkeys: Clinical Evolution and Outcomes. Neurosci Bull. 2017 Feb;33(1):17-27.

  招生需求： 

招收具有生物醫學工程、生物學、醫學、神經生物學、細胞生物學、實驗動物等相關專業背景碩士與博士研究生，常年招收博士後。

另招收電子信息、計算機、生物信息學等專業背景的碩士研究生，主要參與開展行為學表型識别與分析、影像處理與分析、基于生物信息學與機器學習的預測模型、微生理系統模型仿真設計與數據采集分析等方面的研究工作。

聯系方式：fyuee@hainanu.edu.cn