吳錫龍，教授/研究員，博士生導師。2015年在中國科學院長春應用化學研究所獲得博士學位，師從陳學思院士。同年12月至2017年12月在中山大學從事博士後研究工作，2018年1月以“海南大學C類高層次引進人才計劃”入職海南大學。現為微納米智能生物診療團隊負責人，海南省拔尖人才。研究方向為納米藥物、生物水凝膠、智能微納米生物機器人與多模态跨尺度成像、類器官三維培養及其在生物醫藥、再生醫學和疾病精準治療中的應用。相關研究成果以第一或通訊作者發表在Advanced Functional Materials、Biomaterials、Journal of Controlled Release、Chemical Engineering Journal等相關領域國際著名期刊上，獲得多項國家授權發明專利，并主持國家自然科學基金面上項目、地區科學基金項目、海南省基礎與應用基礎研究計劃等多項科研項目，同時擔任國家科技專家庫專家、教育部學位中心學位論文評審專家、教育部科技管理信息系統專家庫專家、海南省科技廳專家庫專家、海南省知識産權局專家庫專家等。
附 團隊簡介：https://hd.hainanu.edu.cn/shengyi/info/1063/1505.htm
研究領域：
納米藥物與分子影像技術，智能水凝膠，功能高分子與微納米材料
代表性學術論文：
1、 Li Z, Yu Z, Wu Y, Wu X*, Wan Y, Yan Y, Wang N. Chemical Engineering Journal, 2020, 390(15): 124648. (IF=13.273，中科院JCR工程技術一區)；
2、 Yu Z, Ye D, Zhao J, Wu X*, Wu Y. Chemical Engineering Journal, 2021, 420, 129691. (IF=13.273，中科院JCR工程技術一區)
3、 Wu Y, Li Q, Liu Y, Li Y, Chen Y, Wu X*, Liu X. International Journal of Pharmaceutics, 2021, 605, 120817. (IF=5.875，中科院JCR藥學一區)
4、 Wu X, He C, Wu Y, Chen X, Cheng J. Advanced Functional Materials, 2015, 25(43): 6744. (IF=18.8084，中科院JCR工程技術一區)；
5、 Wu X, He C, Wu Y, Chen X. Biomaterials, 2016, 75: 148. (IF=12.479，中科院JCR工程技術一區)；
6、 Wu X, Wu Y, Ye H, Yu S, He C, Chen X. Journal of Controlled Release, 2017, 255: 81. (IF=9.7756，中科院JCR醫學一區)；
7、 Wu X, Wu Y, Wang Z, Liu L, Sun C, Chen Y, Wang C. Advanced Healthcare Materials, 2018, 7(11): 1800121. (IF=9.9328，中科院JCR工程技術一區)；
8、 Wu X, Hou J, Li M, Wang J, Kaplan DL, Lu S. Acta Biomaterialia. 2012, 8(6): 2185. (IF=8.9471，中科院JCR工程技術一區)；
部分主持科研項目：
1. 國家自然科學基金面上項目，2021.01-2024.12，主持，在研；
2. 國家自然科學基金地區科學基金項目，2021.01-2024.12，主持，在研；
3. 海南省自然科學基金創新研究團隊項目，2022.03-2025.03，主持，在研；
4. 海南省自然科學基金高層次人才項目，2020/01-2022/12，主持，在研；
5. 武漢光電國家研究中心開放基金，2021/01-2023/12，主持，在研；
6. 海南大學C類高層次人才啟動基金，2018/01-2022/12，主持，在研；
7. 國家自然科學基金青年科學基金項目，2018/01-2020/12，主持，已結題；
8. 中國博士後基金面上項目，2016/01-2017/12，主持，已結題
招生招聘：
團隊招收生物醫學工程、化學、材料學、醫學、藥學或生命科學等相關專業背景的碩博士生、博士後和在編青年博士教師（可直接認定高級職稱）。
聯系方式： wuxilong@hainanu.edu.cn
Xilong Wu, Ph.D.
Professor, School of Biomedical Engineering, Hainan University
No 58, Renmin Avenue, Haikou, 570228, China
Mobile Phone: (+86)173-8460-0130
Email: xilongwu@foxmail.com
RESEARCH INTERESTS
▶ Nanomedicine, Biological Hydrogels, Biomaterials, Drug Delivery;
▶ Nano-Probes for Multimodal Imaging;
▶ Organic Synthetic Polymer Chemistry, Functional Biodegradable Polymers;
▶ Three-Dimensional Culture of Organoids for Drug Screening, Regenerative Medicine and Precision Medicine;
EDUCATION AND RESEARCH EXPERIENCE
Prof. Dr. Xilong Wu is a Professor in the school of biomedical engineering, Hainan University, China. He received his Ph.D. degree from Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS) in 2015 under the supervision of Prof. Xuesi Chen. Then he worked as a postdoctoral research fellow at Sun Yat-sen University (China), before joining Hainan University in the year 2018. His current research interests mainly include the synthesis of nanometer-sized controlled drug delivery systems and biological hydrogels, the development of functionalized nanoprobes for multimodal imaging and three-dimensional culture of organoids for drug screening, regenerative medicine and precision medicine.
SELECTED PUBLICATIONS
▶ Li Z, Yu Z, Wu Y, Wu X*, Wan Y, Yan Y, Wang N. Self-sterilizing diblock polycation-enhanced polyamidoxime shape-stable blow-spun nanofibers for high-performance uranium capture from seawater. Chemical Engineering Journal, 2020, 390(15): 124648.
▶ Yu Z, Ye D, Zhao J, Wu X*, Wu Y. Photocatalytic anti-biofouling coatings with dynamic surfaces of hybrid metal-organic framework nanofibrous mats for uranium (VI) separation from seawater, Chemical Engineering Journal, 2021, 420, 129691.
▶ Wu Y, Li Q, Liu Y, Li Y, Chen Y, Wu X*, Liu X. Targeting hypoxia for sensitization of tumors to apoptosis enhancement through supramolecular biohybrid bacteria, International Journal of Pharmaceutics, 2021, 605, 120817.
▶ Wu X, He C, Wu Y, Chen X, Cheng J. Nanogel-incorporated physical and chemical hybrid gels for highly effective chemo–protein combination therapy. Advanced Functional Materials, 2015, 25(43): 6744.
▶ Wu X, He C, Wu Y, Chen X. Synergistic therapeutic effects of Schiff's base cross-linked injectable hydrogels for local co-delivery of metformin and 5-fluorouracil in a mouse colon carcinoma model. Biomaterials, 2016, 75: 148.
▶ Wu X, Wu Y, Ye H, Yu S, He C, Chen X. Interleukin-15 and cisplatin co-encapsulated thermosensitive polypeptide hydrogels for combined immuno-chemotherapy. Journal of Controlled Release, 2017, 255: 81.
▶ Wu X, Wu Y, Wang Z, Liu L, Sun C, Chen Y, Wang C. A cascade targeting nanocapsule for enhanced photothermal tumor therapy with aid of autophagy inhibition. Advanced Healthcare Materials, 2018, 7(11): 1800121.
▶ Wu X, Hou J, Li M, Wang J, Kaplan DL, Lu S. Sodium dodecyl sulfate-induced rapid gelation of silk fibroin. Acta Biomaterialia. 2012, 8(6): 2185.
SELECTED PAPER TO ACADEMIC CONFERENCES
▶ Wu X, Wu Y, Liu L, Chen Y, "Cellular protease-mediated antitumor drug delivery by hierarchical targeting and pH-sensitive nanosystems", the 2nd International Conference on Nanomedicine, China, Oct 2016, Wuhan, P.R. China.
▶ Wu X, Chu Y, Wu Y, Liu L, Mao H, Chen Y, "Well-defined peptide-conjugated intracellular-acidity-sensitive nanoassemblies for tumor-targeted anticancer drug delivery", 4th Symposium on Innovative Polymers for Controlled Delivery (SIPCD), Sep 2016, Suzhou, P.R. China.
▶ Wu X, He C, Wu Y, Chen X, "Schiff's base cross-linked in situ hydrogels for localized and sustained delivery of anticancer drugs", 2015 National Polymer Academic Report, Oct 2015, Suzhou, P.R. China.
▶ Wu X, He C, Chen X, "Injectable synthetic polypeptide-based hydrogels for biomedical applications", International Symposium on Translational Nanomedicine, Jan 2015, Guangzhou, P.R. China.
▶ Wu X, He C, Chen X, "In situ cross-linking hybrid hydrogels based on naturally-derived polysaccharides and protein", 3rd International Symposium on Polymer Ecomaterials (PEM2014), Aug 2014, Kunming, P.R. China.
▶ Wu, X, Mao L, Lu S, "Preparation and Mechanism of Injectable Silk Hydrogel", The 9th World Biomaterials Congress (WBC), Jun, 2012, Chengdu, P.R. China.
SELECTED PATENTS
▶ China Authorized Patent No. CN 104645348 B: Synthesis and preparation of a kind of novel hydrogel.
▶ China Authorized Patent No. CN 104628885 B: Preparation of a modified dextran-based micelle or drug-carrying nanogel.
▶ China Authorized Patent No. CN 102516777 B: A kind of preparing method of silk fibroin aqueous solution.
▶ China Authorized Patent No. CN 102220017 B: A novel injectable silk fibroin hydrogel and its preparation process and application.
▶ China Authorized Patent No. CN 110846739 B: Design and preparation of anti-shrinkage and antibacterial nanocomposite fibers for extracting uranium from seawater.
▶ China Authorized Patent No. CN 113046857 B: A preparation method of adsorbents with self-renewing antifouling coatings for uranium extraction from seawater.
FUNDING
▶ General Program of National Natural Science Foundation of China (Grant No. 52073077), Period: 2021.01-2024.12;
▶ Regional Program of National Natural Science Foundation of China (Grant No. 22065011), Period: 2021.01-2024.12;
▶ Youth Program of National Natural Science Foundation of China (Grant No. 51703256), Period: 2018.01-2020.12;
▶ Hainan Provincial Natural Science Foundation of China for High-level Talents (Grant No. 2019RC125), Period: 2020.01-2022.12;
▶ Hainan Provincial Natural Science Foundation of China for Scientific Research Innovation Team, Period: 2022.03-2025.03;
▶ Open Project Program of Wuhan National Laboratory for Optoelectronics (Grant NO. 2020WNLOKF020), Period: 2021.01-2023.12;
▶ The Start-up Scientific Research Foundation from Hainan University (Grant No. KYQD(ZR)1828), Period: 2018.01-2022.12;
▶ China Postdoctoral Science Foundation (Grant No. 2016M602578), Period: 2016.01-2017.12;
Recruitment and Qualifications
Recruiting Master/Doctoral Students, Postdoctoral Researchers and Faculty Members in Biomedical Engineering, Chemistry, Materials Science, Medicine, Pharmacy, Life Sciences or Other Related Majors.
