張智紅 博士
365英国上市官网在线教授、博士生導師。1999年同濟醫科大學免疫學專業畢業，獲醫學碩士學位。2003年華中科技大學生物醫學工程專業畢業，獲醫學博士學位。自1999年7月，在華中科技大學生命科學與技術學院和武漢光電國家研究中心工作，曆任講師（2000.7）、副教授（2004.11）、教授（2008.12）。2002年4月作為訪問學者赴美國賓夕法尼亞大學醫學院Dr. Britton Chance實驗室進行為期一年的腫瘤代謝成像合作研究。2007年-2011年期間，曾多次訪問加拿大多倫多大學/安大略癌症研究院Dr. Gang Zheng實驗室，進行多肽-脂質納米載體的合作研究。2020年1月，365英国上市官网在线客座教授。近年來，針對免疫反應可視化研究的重大需求，緻力于發展多分子并行檢測、活體靶向标記和多層次光學成像新方法。建立的免疫光學成像新技術新方法已應用于肝髒、皮膚、腦等相關疾病模型的活體免疫反應可視化研究。
主要研究方向
1）完整肝髒三維結構與免疫功能的可視化研究；
2）腫瘤免疫的活體光學分子成像；
3）靶向标記與調控免疫細胞的多功能脂質納米探針/藥物/疫苗。
免疫成像與診療團隊成員
王朝輝 教授（高聘） https://hd.hainanu.edu.cn/shengyi/info/1106/1842.htm
餘 祥 教授（高聘） https://hd.hainanu.edu.cn/shengyi/info/1106/2271.htm
劉 征 研究員（高聘） https://hd.hainanu.edu.cn/shengyi/info/1106/2282.htm
彭星舟 副研究員 https://hd.hainanu.edu.cn/shengyi/info/1107/1118.htm
戴豔鋒 博士後 https://hd.hainanu.edu.cn/shengyi/info/1131/1499.htm
徐夢麗 博士後 https://hd.hainanu.edu.cn/shengyi/info/1131/2463.htm
黃松林 博士後 https://hd.hainanu.edu.cn/shengyi/info/1131/2612.htm
主持國家科研項目
1) 國家重點研發計劃“變革性技術關鍵科學問題”重點專項, “完整肝髒三維結構與功能信息的精準介觀測量”，2018/05-2023/04，2776萬元
2) 國家自然科學基金重點項目，“光學成像可視化研究肝轉移過程中腫瘤異質性與微環境的時空變化”，2024/01-2028/12、216萬元
3) 國家傑出青年科學基金，“腫瘤免疫光學分子成像”，2017/01-2021/12、350萬元
4) 國家自然科學基金重大研究計劃重點支持項目，2015/01-2018/12、300萬元
5) 國家自然科學基金面上項目，2012/01-2015/12、55萬元
6) 國家科技支撐計劃課題，2012/01-2014/12、362萬元
7) 教育部“新世紀優秀人才支持計劃”， 2009/01-2011/12、50萬元
8) 國家自然科學基金面上項目，2008/01-2010/12、38萬元
學術論文
在Nature Communications、Science Advances、Light: Science & Applications、eLife、Theranostics、Advanced Science、ACS Nano、Autophagy和Brain Behavior and Immunity等SCI期刊上發表第一或通訊作者（含并列）論文60多篇。
第一或通訊作者的代表性論文（1并列第一作者；*通訊作者）：
1) Zheng Liu1, Zhan Fan1, Jinxin Liu, Jialu Wang, Mengli Xu, Xinlin Li, Yilun Xu, Yafang Lu, Chenlu Han, Zhihong Zhang*. Melittin-carrying nanoparticle suppress T cell-driven immunity in a murine allergic dermatitis model. Advanced Science, 10, 2204184, 2023.
2) Songlin Huang1, Borui Li1, Zheng Liu1, Mengli Xu, Dong Lin, Jiahong Hu, Dongjian Cao, Qi Pan, Jing Zhang, Jing Yuan, Qingming Luo*, Zhihong Zhang*. Three-dimensional mapping of hepatic lymphatic vessels and transcriptome profiling of lymphatic endothelial cells in healthy and diseased livers. Theranostics, 13(2): 639-658, 2023.
3) Junjie Wang1, Xingzhou Peng1, Jianshuang Wei, Yanfeng Dai, Songlin Huang, Deqiang Deng, Zhan Fan, Yuehong Leng, Jing Ai, Zhenzhen Cai, Maosong Qiu, Shizhen Chen, Xiaoquan Yang*, Zhihong Zhang*. In situ phagocyte-mediated deep tumor penetration assisted by ApoA-1 mimetic peptide-modified silicasome. Nano Today. 50: 101864,2023.
4) Qi Pan, Borui Li, Dong Lin, Ya-Ru Miao, Tao Luo, Tao Yue, Qingming Luo, An-Yuan Guo*, Zhihong Zhang*. scLiverDB: a database of human and mouse liver transcriptome landscapes at single-cell resolution. Small Methods, 22014, 2023.
5) Hao Zheng1, Songlin Huang1, Jing Zhang, Ren Zhang, Jialu Wang, Jing Yuan, Anan Li, Xin Yang*, Zhihong Zhang*. C1M2: a universal algorithm for 3D instance segmentation, annotation, and quantification of irregular cells. Science China-Life Sciences. 2023.
6) Yanfeng Dai, Xiang Yu, Yuehong Leng, Xingzhou Peng, Junjie Wang, Yifan Zhao, Juan Chen, Zhihong Zhang*. Effective treatment of metastatic sentinel lymph nodes by dualtargeting melittin nanoparticles. Journal of Nanobiotechnology. 21: 254, 2023.
7) Jian Li1, Lisen Lu1, Kyle Binder, Jian Xiong, Lilin Ye, Yan H. Cheng, Sonia Majri-Morrison, Wei Lu, Jae Lee, Zhihong Zhang*, Yuzhang Wu*, Lixin Zheng*, and Michael J. Lenardo*. Mechanisms of antigen-induced reversal of CNS inflammation in experimental demyelinating disease. Science Advances, 2023.
8) Bolei Dai1, Ren Zhang1, Shuhong Qi*, Lei Liu, Xian Zhang, Deqiang Deng, Jie Zhang, Yilun Xu, Fanxuan Liu, Zheng Liu, Qingming Luo, Zhihong Zhang*. Intravital molecular imaging reveals that ROS-caspase-3-GSDME-induced cell punching enhances humoral immunotherapy targeting intracellular tumor antigens. Theranostics, 12(17): 7603-7623, 2022.
9) Zheng Liu1, Mengli Xu1, Songlin Huang1, Qi Pan, Chong Liu, Fanxin Zeng, Zhan Fan, Yafang Lu, Jialu Wang, Jinxin Liu, Xinlin Li, Qingming Luo*, Zhihong Zhang*. Mesoscale visualization of three-dimensional microvascular architecture and immunocyte distribution in intact mouse liver lobes. Theranostics 2022; 12(12):5418-5433. (封面文章)
10) Deqiang Deng1, Bolei Dai1, Jianshuang Wei, Xuenan Yuan, Xiaoquan Yang, Shuhong Qi*, Zhihong Zhang*. A drawer-type abdominal window with an acrylic/resin coverslip enables long-term intravital fluorescence/photoacoustic imaging of liver. Nanophotonics, 10(12): 3369–3381, 2021.
11) Lei Liu, Bolei Dai, Ruixue Li, Zheng Liu, Zhihong Zhang*. Intravital molecular imaging reveals the restrained capacity of CTLs in the killing of tumor cells in the liver. Theranostics, 11(1): 194-208, 2021.
12) Vasiliki Staikopoulos1, Sha Qiao1, Jiajun Liu, Xianlin Song, Xiaoqun Yang, Qingming Luo, Mark R Hutchinson, Zhihong Zhang*. Graded peripheral nerve injury creates proportional mechanical allodynia to the progression and severity of microglial activity within the spinal cord of male mice. Brain Behavior and Immunity. 91:568-577, 2021.
13) Haiming Luo1,*, Lisen Lu1, Ni Liu, Qingqing Li, Xiaoquan Yang, Zhihong Zhang*. Curcumin loaded sub-30 nm targeting therapeutic lipid nanoparticles for synergistically blocking nasopharyngeal cancer growth and metastasis. Journal of Nanobiotechnology, 19:224, 2021.
14) Yanfeng Dai1, Xiang Yu1, Jianshuang Wei1, Fanxin Zeng, Yiran Li, Xiaoquan Yang, Qingming Luo*, Zhihong Zhang*. Metastatic status of sentinel lymph nodes in breast cancer determined with photoacoustic microscopy via dual-targeting nanoparticles. Light: Science & Applications. 9:164, 2020.
15) Lisen Lu1, Shuhong Qi1, Yuzhou Chen, Haiming Luo, Songlin Huang, Xiang Yu, Qingming Luo, Zhihong Zhang*. Targeted immunomodulation of inflammatory monocytes across the blood-brain barrier by curcumin-loaded nanoparticles delays the progression of experimental autoimmune encephalomyelitis. Biomaterials. 245:119987, 2020.
16) Xiang Yu1, Yanfeng Dai1, Yifan Zhao, Shuhong Qi, Lei Liu, Qingming Luo, Zhihong Zhang*. Melittin-lipid nanoparticles target to lymph node and elicit a systemic anti-tumor immune response. Nature Communications. 11, 1110, 2020.
17) Shuhong Qi1, Lisen Lu1, Feifan Zhou, Yuzhou Chen, Mengli Xu, Lu Chen, Xiang Yu, Wei R. Chen*, Zhihong Zhang*. Neutrophil infiltration and whole-cell vaccine elicited by N-dihydrogalactochitosan combined with NIR phototherapy to enhance antitumor immune response and T cell immune memory. Theranostics. 10(4): 1814-1832, 2020.
18) Qiaoya Lin1, Deqiang Deng1, Xianlin Song, Bolei Dai, Xiaoquan Yang, Qingming Luo*, Zhihong Zhang*. Self-Assembled “Off/On” Nanopomegranate for in vivo photoacoustic and fluorescence imaging: strategic arrangement of kupffer cells in mouse hepatic lobules. ACS Nano. 13 (2), 1526–1537, 2019.
19) Xiang Yu, Lu Chen, Jianqiao Liu, Bolei Dai, Guoqiang Xu, Guanxin Shen, Qingming Luo*, Zhihong Zhang*. Immune modulation of liver sinusoidal endothelial cells by melittin nanoparticles suppresses liver metastasis. Nature Communications. 10:574, 2019.
20) Sha Qiao1, Yuan Qian1, Guoqiang Xu, Qingming Luo, Zhihong Zhang*. Long-term characterization of activated microglia/macrophages facilitating the development of experimental brain metastasis through intravital microscopic imaging. Journal of Neuroinflammation. 16:4, 1-14, 2019.
21) Zheng Liu, Fei Yang, Hao Zheng, Zhan Fan, Sha Qiao, Lei Liu, Juan Tao, Qingming Luo*, Zhihong Zhang*. Visualization of T cell-regulated monocyte clusters mediating keratinocyte death in acquired cutaneous immunity. Journal of Investigative Dermatology. 138: 1328-1337, 2018. (封面文章)
22) Yuan Qian1, Sha Qiao1, Yanfeng Dai, Guoqiang Xu, Bolei Dai, Lisen Lu, Xiang Yu, Qingming Luo, Zhihong Zhang*. Molecular-targeted immunotherapeutic strategy for melanoma via dual-Targeting nanoparticles delivering small interfering RNA to tumor-associated macrophages. ACS Nano, 11(9), 9536−9549, 2017.
23) Liang Wang, Lei Liu, Lingsong Qin, Qingming Luo, Zhihong Zhang*. Visualization of reticulophagy in living cells using an endoplasmic reticulum-targeted p62 mutant. Science China-Life Sciences. 60(4):333-344, 2017. (封面文章)
24) Shuhong Qi1, Hui Li1, Lisen Lu, Zhongyang Qi, Lei Liu, Lu Chen, Guanxin Shen, Ling Fu, Qingming Luo*, Zhihong Zhang*. Long-term intravital imaging of the multicolor-coded tumor microenvironment during combination immunotherapy. eLife, 5: e14756, 2016.
25) Honglin Jin, Yuan Qian, Yanfeng Dai, Sha Qiao, Chuan Huang, Lisen Lu, Qingming Luo, Jing Chen*, Zhihong Zhang*. Magnetic enrichment of dendritic cell vaccine in lymph node with fluorescent-magnetic nanoparticles enhanced cancer immunotherapy. Theranostics, 6(11): 2000-2014, 2016.
26) Fei Yang1, Shun Liu1, Xiuli Liu1, Lei Liu1, Meijie Luo, Shuhong Qi, Guoqiang Xu, Sha Qiao, Xiaohua Lv, Xiangning Li, Ling Fu, Qingming Luo*, Zhihong Zhang*. In vivo visualization of tumor antigen-containing microparticles generated in fluorescent-protein-elicited immunity. Theranostics. 6(9):1453-1466, 2016.
27) Yuan Qian1, Honglin Jin1, Sha Qiao, Yanfeng Dai, Chuan Huang, Lisen Lu, Qingming Luo*, Zhihong Zhang*. Targeting dendritic cells in lymph node with an antigen peptide-based nanovaccine for cancer immunotherapy. Biomaterials. 98, 171-183, 2016.
28) Haiming Luo, Lisen Lu, Fei Yang, Liang Wang, Xiaoquan Yang, Qingming Luo, Zhihong Zhang*. Nasopharyngeal cancer-specific therapy based on fusion peptide-functionalized
29) Meijie Luo, Zhihong Zhang*, Hui Li, Sha Qiao, Zheng Liu, Ling Fu, Guanxin Shen, Qingming Luo*. Multi-scale optical imaging of the delayed type hypersensitivity reaction attenuated by rapamycin. Theranostics. 4(2): 201-214, 2014.
30) Chuan Huang, Honglin Jin, Yuan Qian, Shuhong Qi, Haiming Luo, Qingming Luo, Zhihong Zhang*. Hybrid melittin cytolytic peptide-driven ultrasmall lipid nanoparticles block melanoma growth in vivo. ACS Nano, 7(7): 5791–5800, 2013.
31) Ying Zheng#, Yanyan Liu#, Honglin Jin#, Shaotao Pan, Yuan Qian, Chuan Huang, Yixin Zeng, Qingming Luo, Musheng Zeng*, Zhihong Zhang*. Scavenger receptor B1 is a potential biomarker of human nasopharyngeal carcinoma and its growth is inhibited by HDL-mimetic nanoparticles. Theranostics. 3(7):477-486, 2013.
32) Liang Wang1, Min Chen1, Jie Yang, Zhihong Zhang*. LC3 fluorescent puncta in autophagosomes or in protein aggregates can be distinguished by FRAP analysis in living cells. Autophagy. 9(5): 756-769, 2013.
33) Ting Su, Shaotao Pan, Qingming Luo, Zhihong Zhang*. Monitoring of dual bio-molecular events using FRET biosensors based on mTagBFP/sfGFP and mVenus/mKOκ fluorescent protein pairs. Biosensors and Bioelectronics. 46: 97-101, 2013.
34) Haiming Luo, Jiyun Shi, Honglin Jin, Di Fan, Lisen Lu, Fan Wang*, Zhihong Zhang*. An 125I-labeled octavalent peptide fluorescent nanoprobe for tumor-homing imaging in vivo. Biomaterials. 33 (19): 4843-4850, 2012.
35) Zhihong Zhang1, Juan Chen1, Lili Ding, Honglin Jin, Jonathan F. Lovell, Ian Corbin, Weiguo Cao, Pui-Chi Lo, Mi Yang, Ming-Sound Tsao, Qingming Luo, Gang Zheng*, HDL-mimicking peptide-lipid nanoparticles with improved tumor targeting. Small. 6(3): 430-437, 2010.
36) Zhihong Zhang, Weiguo Cao, Honglin Jin, Jonathan F. Lovell, Mi Yang, Lili Ding, Juan Chen, Ian Corbin, Qingming Luo, Gang Zheng*. Biomimetic nanocarrier for direct cytosolic drug delivery. Angewandte Chemie International Edition. 48(48): 9171-9175, 2009.
37) Zhihong Zhang, Hui Li, Qian Liu, Lanlan Zhou, Ming Zhang, Qingming Luo*, Jerry Glickson, Britton Chance, Gang Zheng. Metabolic imaging of tumors using intrinsic and extrinsic fluorescent markers. Biosensors & Bioelectronics. 20(3): 643-650, 2004.
38) Zhihong Zhang, Dana Blessington, Theresa M. Busch, Jerry Glickson, Qingming Luo*, Britton Chance and Gang Zheng. Redox ratio of mitochondria as an indicator for the response of Photodynamic Therapy. Journal of Biomedical Optics. 9(4): 772-778, 2004.
專著與綜述
1) Mengli Xu1, Zheng Liu1, Xinlin Li, Xinru Wang, Xuenan Yuan, Chenlu Han, Zhihong Zhang*. Three-dimensional structure of liver vessels and spatial distribution of hepatic immune cells. Journal of Innovative Optical Health Sciences. 2330006, 2023.
2) Xuenan Yuan, Xiang Yu, Bolei Dai, Zhihong Zhang*. “Advances in intravital imaging of liver immunity using optical microscopy and labeling methods”. iRADIOLOGY, 1(1): 61-77, 2023.
3) Xingzhou Peng1, Junjie Wang1, Feifan Zhou, Qian Liu*, Zhihong Zhang*.Nanoparticle-based approaches to target the lymphatic system for antitumor treatment. Cellular and Molecular Life Sciences, 78(12):5139-5161, 2021.
4) 林巧雅, 黃松林, 駱清銘, 張智紅*. 肝髒免疫的活體顯微光學成像研究進展. 生物化學與生物物理進展. 44(12): 1056~1065, 2017. (封面文章)
5) Zhihong Zhang, Qingming Luo, Chapter 1: Fluorescent Protein Labeling Techniques. “ADVANCES IN MOLECULAR BIOPHOTONICS”. ISBN 978-3-11-030438-1, 2017 Shanghai Jiao Tong University Press and Walter de Gruyter GmbH, Berlin/Boston
6) 張智紅、韓岩梅，免疫學新技術進展及發展趨勢，《2014-2015免疫學學科發展報告》第十八章，書号：ISBN 978-7-5046-7093-9/R·1876，中國科學技術出版社，2016年4月出版。
7) 張智紅、駱清銘，新型熒光蛋白标記技術，《生物分子光子學研究前沿》第一章，書号：ISBN978-7-313-11756-4，上海交通大學出版社，2014年出版.
8) 張智紅、呂群燕、駱清銘、程京、曹雪濤，細胞功能的可視化及信息整合分析——第69次“雙清論壇”綜述，中國科學基金，26(4): 195-198, 2012.
9) 駱清銘、張智紅，免疫光子學進展. 光學學報. 31: 900114, 2011.
獲獎與榮譽稱号
2006年獲湖北省優秀博士論文《基于内源性和外源性熒光分子的腫瘤代謝成像》
2008年教育部“新世紀優秀人才支持計劃”入選者
2008年獲湖北省自然科學一等獎《用于藥物篩選和藥效評價的光學分子成像動态監測理論與方法研究》，第二完成人
2010年獲國家自然科學二等獎《生物功能的飛秒激光光學成像機理研究》，第五完成人
2016年國家傑出青年科學基金獲得者
研究生培養
1）指導的博士學位論文《EGF誘導的Src信号動力學的實時光學成像研究》（作者：蘇挺）被評為2013年湖北省優秀博士學位論文；
2）指導的博士學位論文《用于鼻咽癌高效靶向診療的多肽-脂質納米探針的研制》（作者：駱海明）被評為2014年湖北省優秀博士學位論文；
3）培養的2013年畢業博士生駱海明，2017年獲國家級青年項目；
4）培養的2012年畢業博士生金紅林，2020年獲國家級青年項目；
5）培養的2019年畢業博士生餘祥，2021年獲第十屆中國免疫學會學術獎“青年學者獎”
學術兼職
學術期刊Cellular & Molecular Immunology、European Journal of Nuclear Medicine and Molecular Imaging、iRadiology、Bioconjugate Chemistry、《生物化學與生物物理進展》和《中國免疫學雜志》編委會委員。國際光學工程學會（SPIE）Photonics West “Biophotonics and Immune Responses”會議的委員會成員（Program Committee Member）（會議地點：美國舊金山）。中國抗癌協會全國腫瘤精準治療專委會常務委員、中國認知科學學會分子影像分會常務理事、中國老年學和老年醫學學會老年病學分會腫瘤基礎及轉化研究專家委員會常委、中國電子學會生命電子學分會常務委員。
招生需求
招收生物、醫學、生物醫學工程及相關專業的碩士生和博士生2-3人，博士後2人。
聯系方式：zhzhang@hainanu.edu.cn
