李向甯，365英国上市官网在线教授，博士生導師，華中科技大學蘇州腦空間信息研究院生物平台主任，中國生物醫學工程學會類器官與器官芯片分會副主任委員。2007年畢業于華中科技大學，獲生物醫學工程專業博士學位。2007-2023年于華中科技大學工作，曆任講師、副教授、教授。2010-2012年紐約州立大學布法羅分校做博士後研究，2016年于美國冷泉港實驗室做訪問學者。2008年獲湖北省優秀博士學位論文獎，2017年指導本科生獲得湖北省優秀學士論文。
主要研究：
從事神經環路結構、功能與病理機制研究。1)緻力于開發适用于大體積生物組織的樣本處理策略，探索齧齒類、靈長類整體器官結構和組織模式；2)結合顯微光學切片成像、光電聯合刺激、類器官等技術，在在介觀水平解析學習與記憶的神經環路基礎、神經退行性疾病機制等。相關工作以第一作者或通訊作者發表于Nature Neuroscience, Nature Communications, PNAS, Science Bulletin等。合作文章發表于Nature, Nature Methods, Neuron等頂級期刊。
主持國家自然科學基金青年基金、面上項目，科技部科技創新2030重大項目，參與了國家自然科學基金重大項目、國家重大科學儀器設備開發專項等項目。
代表性文章（*為通訊作者,#為同等貢獻）：
1. Zhao Peilin, Jiang Tao, Wang Huading, Jia Xueyan, Li Anan, Li Xiangning*, Gong Hui*. Upper brainstem cholinergic neurons project to ascending and descending circuits. BMC biology, 2023, 21(1):135.
2. Yao Mei, Ayizuohere Tudi, Jiang Tao, An Xu, Sun Qingtao, Li Anan+, Huang Z. Josh, Gong Hui*, Li Xiangning*, Long-range connectome of pyramidal neurons in the sensorimotor cortex. iScience, 2023, 26(4):106316.
3. Chen Siqi, Liu Guangcai, Li Anan, Liu Zhixiang, Long Ben, Yang Xiaoquan, Gong Hui, Li Xiangning*, Three-dimensional mapping in multi-samples with large-scale imaging and multiplexed post staining. Commun Biol, 2023, 6(1):148.
4. Tian Jiaojiao, Chen Yingying, Jiang Tao, Jia Xueyan, Gong Hui*, Li Xiangning*, (2023) Low-temperature resin embedding of the whole brain for various precise structures dissection. iScience, 2023, 26(5):106705.
5. Jiaojiao Tian#, Miao Ren#, Peilin Zhao#, Shukang Luo, Yingying Chen, Xiaofeng Xu, Tao Jiang, Qingtao Sun, Anan Li, Hui Gong, Xiangning Li*, Qingming Luo*. Dissection of the long-range projections of specific neurons at the synaptic level in the whole mouse brain. PNAS, 2022, 119 (40): e2202536119.
6. Sun Qingtao, Zhang Jianping, Li Anan, Yao Mei, Liu Guangcai, Chen Siqi, Luo Yue, Wang Zhi, Gong Hui, Li Xiangning*, Luo Qingming*. Acetylcholine deficiency disrupts extratelencephalic projection neurons in the prefrontal cortex in a mouse model of Alzheimer’s disease. Nature Communications, 2022, 13, 998.
7. Can Zhou, Xiaoquan Yang, Shihao Wu, Qiuyuan Zhong, Ting Luo, Anan Li, Guangcai Liu, Qingtao Sun, Pan Luo, Lei Deng, Hong Ni, Chaozhen Tan, Jing Yuan, Qingming Luo, Xintian Hu*, Xiangning Li*, Hui Gong*, Continuous subcellular resolution three-dimensional imaging on intact macaque brain, Science Bulletin, 2022, 67(1): 85-96
8. Y. Zhang, X. Xing, B. Long, Y. Cao, S. Hu, Xiangning Li, Y. Yu, D. Tian, B. Sui, Z. Luo, W. Liu, L. Lv, Q. Wu, J. Dai, M. Zhou, H. Han, Z. F. Fu, H. Gong, F. Bai and L. ZhaoA spatial and cellular distribution of rabies virus infection in the mouse brain revealed by fMOST and single-cell RNA sequencing. Clinical and translational medicine, 2022 12(1):e700.
9. Zhao Peilin, Wang Huading, Li Anan, Sun Qingtao, Jiang Tao, Li Xiangning*, Gong Hui*. The Mesoscopic Connectome of the Cholinergic Pontomesencephalic Tegmentum. Frontiers in neuroanatomy 16:843303.
10. Ma H, et al. (2022) Multiscale Analysis of Cellular Composition and Morphology in Intact Cerebral Organoids. Biology (Basel) 11(9).
11. Yang Yang, Jiang Tao, Jia Xueyan, Li Xiangning*, Gong Hui*. Whole-Brain Connectome of GABAergic Neurons in the Mouse Zona Incerta. Neuroscience Bulletin, 2022. doi.org/10.1007/s12264-022-00930-w
12. Foster, N. N., Barry, J., Korobkova, L., Garcia, L., Gao, L., Becerra, M., Sherafat, Y., Peng, B., Li Xiangning, Choi, J. H., Gou, L., Zingg, B., Azam, S., Lo, D., Khanjani, N., Zhang, B., Stanis, J., Bowman, I., Cotter, K., Cao, C., Yamashita, S., Tugangui, A., Li, A., Jiang, T., Jia, X., Feng, Z., Aquino, S., Mun, H. S., Zhu, M., Santarelli, A., Benavidez, N. L., Song, M., Dan, G., Fayzullina, M., Ustrell, S., Boesen, T., Johnson, D. L., Xu, H., Bienkowski, M. S., Yang, X. W., Gong, H., Levine, M. S., Wickersham, I., Luo, Q., Hahn, J. D., Lim, B. K., Zhang, L. I., Cepeda, C., Hintiryan, H. and Dong, H. W. The mouse cortico-basal ganglia-thalamic network. Nature, 2021 598(7879):188-194.
13. Munoz-Castaneda, R., Zingg, B., Matho, K. S., Chen, X., Wang, Q., Foster, N. N., Li, A., Narasimhan, A., Hirokawa, K. E., Huo, B., Bannerjee, S., Korobkova, L., Park, C. S., Park, Y. G., Bienkowski, M. S., Chon, U., Wheeler, D. W., Li Xiangning, Wang, Y., Naeemi, M., Xie, P., Liu, L., Kelly, K., An, X., Attili, S. M., Bowman, I., Bludova, A., Cetin, A., Ding, L., Drewes, R., D'Orazi, F., Elowsky, C., Fischer, S., Galbavy, W., Gao, L., Gillis, J., Groblewski, P. A., Gou, L., Hahn, J. D., Hatfield, J. T., Hintiryan, H., Huang, J. J., Kondo, H., Kuang, X., Lesnar, P., Li, X., Li, Y., Lin, M., Lo, D., Mizrachi, J., Mok, S., Nicovich, P. R., Palaniswamy, R., Palmer, J., Qi, X., Shen, E., Sun, Y. C., Tao, H. W., Wakemen, W., Wang, Y., Yao, S., Yuan, J., Zhan, H., Zhu, M., Ng, L., Zhang, L. I., Lim, B. K., Hawrylycz, M., Gong, H., Gee, J. C., Kim, Y., Chung, K., Yang, X. W., Peng, H., Luo, Q., Mitra, P. P., Zador, A. M., Zeng, H., Ascoli, G. A., Josh Huang, Z., Osten, P., Harris, J. A. and Dong, H. W. Cellular anatomy of the mouse primary motor cortex. Nature, 2021, 598(7879):159-166.
14. Peng, H., Xie, P., Liu, L., Kuang, X., Wang, Y., Qu, L., Gong, H., Jiang, S., Li, A., Ruan, Z., Ding, L., Yao, Z., Chen, C., Chen, M., Daigle, T. L., Dalley, R., Ding, Z., Duan, Y., Feiner, A., He, P., Hill, C., Hirokawa, K. E., Hong, G., Huang, L., Kebede, S., Kuo, H. C., Larsen, R., Lesnar, P., Li, L., Li, Q., Li Xiangning, Li, Y., Li, Y., Liu, A., Lu, D., Mok, S., Ng, L., Nguyen, T. N., Ouyang, Q., Pan, J., Shen, E., Song, Y., Sunkin, S. M., Tasic, B., Veldman, M. B., Wakeman, W., Wan, W., Wang, P., Wang, Q., Wang, T., Wang, Y., Xiong, F., Xiong, W., Xu, W., Ye, M., Yin, L., Yu, Y., Yuan, J., Yuan, J., Yun, Z., Zeng, S., Zhang, S., Zhao, S., Zhao, Z., Zhou, Z., Huang, Z. J., Esposito, L., Hawrylycz, M. J., Sorensen, S. A., Yang, X. W., Zheng, Y., Gu, Z., Xie, W., Koch, C., Luo, Q., Harris, J. A., Wang, Y. and Zeng, H. Morphological diversity of single neurons in molecularly defined cell types. Nature, 2021, 598(7879):174-181.
15. Qiuyuan Zhong, Anan Li, Rui Jin, Dejie Zhang, Xiangning Li, Xueyan Jia, Zhangheng Ding, Pan Luo, Can Zhou, Chengyu Jiang, Zhao Feng, Zhihong Zhang, Hui Gong, Jing Yuan, Qingming Luo, High-definition imaging using line-illumination modulation microscopy. Nat Methods, 2021, 18 (3): 309-+.
16. Peng Chen, Shihao Lou, Zhao-Huan Huang, Zhenni Wang, Qing-Hong Shan, Yu Wang, Yupeng Yang, Xiangning Li, Hui Gong, Yan Jin, Zhi Zhang, Jiang-Ning Zhou*, Prefrontal cortex corticotropin-releasing factor neurons control behavioral style selection under challenging situations, Neuron, 2020, 106, 301-31
17. Long Ben, Jiang Tao, Zhang Jianmin, Chen Siqi, Jia Xueyan, Xu Xiaofeng, Luo Qingming, Gong Hui, Li Anan, Li Xiangning*. Mapping the Architecture of Ferret Brains at Single-Cell Resolution. Front. Neurosci. 2020, 14:322. doi: 10.3389/fnins.2020.00322
18. Ting Luo, Lei Deng, Anan Li, Can Zhou, Shuai Shao, Qingtao Sun, Hui Gong, Xiaoquan Yang, Xiangning Li*，Scalable Resin Embedding Method for Large-Volume Brain Tissues with High Fluorescence Preservation Capacity. iScience, 2020, 23:101717
19. Duan Zhuonan, Li Anan, Gong Hui, Li Xiangning*. A Whole-brain Map of Long-range Inputs to GABAergic Interneurons in the Mouse Caudal Forelimb Area. Neuroscience Bulletin. 2020. 36, 493-505
20. Sun Qingtao#, Li Xiangning#, Ren Miao, Zhao Mengting, Zhong Qiuyuan, Ren Yuqi, Luo Pan, Ni Hong, Zhang Xiaoyu, Zhang Chen, Yuan Jing, Li Anan, Luo Minmin, Gong Hui, Luo Qingming, A whole-brain map of long-range inputs to GABAergic interneurons in the mouse medial prefrontal cortex. Nature Neuroscience, 2019, 22:1357-1370.
21. Luo Pan, Li Anan, Zheng Yanxiao, Han Yutong, Tian Jiaojiao, Xu Zhengchao, Gong Hui, Li Xiangning*, Whole Brain Mapping of Long-Range Direct Input to Glutamatergic and GABAergic Neurons in Motor Cortex. Frontiers in Neuroanatomy, 2019, 13:44.
22. Li Xiangning#, Yu Bin#, Sun Qingtao, Zhang Yalun, Ren Miao, Zhang Xiaoyan, Li Anan, Yuan Jing, Madisen L., Luo Qingming, Zeng Hongkui, Gong Hui, Qiu Zilong, Generation of a whole-brain atlas for the cholinergic system and mesoscopic projectome analysis of basal forebrain cholinergic neurons. PNAS, 2018, 115(2): 415-420.
招生專業：
生物醫學工程、生物學、化學等相關專業
聯系方式：lixiangning@hainanu.edu.cn
