駱海明，海南大學生物醫學工程教授，博士生導師。入選國家高層次人才計劃、湖北省百人計劃。2013年獲得華中科技大學生物醫學工程專業博士學位（湖北省優秀博士學位論文）。2013-2015年先後在美國威斯康辛大學麥迪遜分校與美國哈佛醫學院麻省總醫院進行博士後研究；2018年03華中科技大學教授；2024年6月365英国上市官网在线教授。在Science Advances, PNAS、Clinical Cancer Research、Journal of Nuclear Medicine、Biosensors & Bioelectronics、Theranostics、Journal of Nanobiotechnology等期刊上發表SCI論文20多篇。獲得授權中國發明專利7項。目前研究方向：阿爾茨海默病的早期超靈敏檢測與防治，包括：1、超靈敏檢測方法、傳感器件、微創采樣的研發；2、單克隆抗體藥物、疫苗以及活細胞遞送系統；3、阿爾茨海默病的發病機制及其病程标記與示蹤成像。
阿爾茨海默病方向代表性論文（*為通訊作者）
1. Hu Shun, Zhang Liding, Su Ying, Liang Xiaohan, Yang Jie, Luo Qingming, Luo Haiming*. Sensitive detection of multiple blood biomarkers via immunomagnetic exosomal PCR for the diagnosis of Alzheimer’s disease. Science Advances. 2024, 10(13):eabm3088.
2. Zhang Liding, Cao Kai, Su Ying, Hu Shun, Liang Xiaohan, Luo Qingming, Luo Haiming*. Colorimetric and surface-enhanced Raman scattering dual-mode magnetic immunosensor for ultrasensitive detection of blood phosphorylated tau in Alzheimer's disease. Biosensor and Bioelectronics, 2023;222:114935.
3. Hu Shun, Yang Changwen, Li Yanqing, Luo Qingming, Luo Haiming*. Nanozyme sensor array based on manganese dioxide for the distinction between multiple amyloid β peptides and their dynamic aggregation process. Biosensor and Bioelectronics. 2022,199:113881
4. Zhang Liding, Du Xuewei, Su Ying, Niu Shiqi, Li Yanqing, Liang Xiaohan, Luo Haiming*. Quantitative assessment of AD markers using naked eyes: point-of-care testing with paper-based lateral flow immunoassay. Journal of Nanobiotechnology. 2021, 19(1):366
5. Hu Shun, Yang Changwen, Luo Haiming*. Current trends in blood biomarker detection and imaging for Alzheimer's disease. Biosensor and Bioelectronics. 2022, 210:114278
6. Zhang Liding, Su Ying, Liang Xiaohan, Cao Kai, Luo Qingming, Luo Haiming*. Ultrasensitive and point-of-care detection of plasma phosphorylated tau in Alzheimer's disease using colorimetric and surface-enhanced Raman scattering dual-readout lateral flow assays. Nano Research. 2023;16(5):7459-7469
7. Zhang Liding, Cao Kai, Xie Jun, Liang Xiaohan, Gong Hui, Luo Qingming*, Luo Haiming*. Aβ42 and ROS dual-targeted multifunctional nanocomposite for combination therapy of Alzheimer's disease. Journal of Nanobiotechnology, 2024, 22(1):278
8. Liu Ni, Liang Xiaohan, Yang Changwen, Hu Shun, Luo Qingming, Luo Haiming*. Dual-targeted magnetic mesoporous silica nanoparticles reduce brain amyloid-β burden via depolymerization and intestinal metabolism. Theranostics. 2022, 12: 6646-6664
9. Liang Xiaohan, Luo Haiming*. Optical Tissue Clearing: Illuminating Brain Function and Dysfunction. Theranostics. 2021,11(7):3035-3051
10. Zhang Liding, Yang Changwen, Li Yanqing, Niu Shiqi, Liang Xiaohan, Zhang Zhihong, Luo Qingming, Luo Haiming*. Dynamic changes in the levels of amyloid-β42 species in the brain and periphery of APP/PS1 mice and their significance for Alzheimer's disease. Frontiers in Molecular Neuroscience. 2021, 14:723317
活體成像檢測方向代表性文章
1. Luo Haiming#, Hernandez Reinier#, Hong Hao, Graves A Stephen, Yang Yunan, Christopher G England, Theuer P Charles, Nickles J Robert, Cai Weibo. Noninvasive brain cancer imaging with a bispecific antibody fragment, generated via click chemistry. Proceedings of the National Academy of Sciences, 2015, 112(41):12806-11.
2. Luo Haiming, Christopher G England, Shi Sixiang, Graves A Stephen, Hernandez Reinier, Liu Bai, Theuer P Charles, Wong C Hing, Nickles J Robert, Cai Weibo. Dual Targeting of Tissue Factor and CD105 for Preclinical PET Imaging of Pancreatic Cancer. Clinical Cancer Research, 2016, 22(15):3821-30.
3. Luo Haiming, Hong Hao, Slater R Michael, Graves A Stephen, Shi Sixiang, Yang Yunan, Nickles J Robert, Fan Frank, Cai Weibo. PET of c-Met in cancer with 64Cu-labeled Hepatocyte Growth Factor. Journal of Nuclear Medicine, 2015, 56(5):758-63.
4. Luo Haiming#, Christopher G England#, Graves A Stephen, Sun Haiyan, Liu Glenn, Nickles J Robert, Cai Weibo. PET of VEGFR2 in cancer with 64Cu-labeled ramucirumab. Journal of Nuclear Medicine, 2016, 57(2):285-90.
5. Luo Haiming*, Yang Changwen, Kuang Dong, Chan W. Annie*. Visualizing dynamic changes in PD-L1 expression in non-small-cell lung carcinoma with radiolabeled recombinant human PD1. European Journal of Nuclear Medicine and Molecular Imaging. 2022, 49(8):2735-2745
6. Luo Haiming, Lu Lisen, Yang Fei, Wang Liang, Yang Xiaoquan, Luo Qingming, Zhang Zhihong. Nasopharyngeal Cancer-Specific Therapy Based on Fusion Peptide-Functionalized Lipid Nanoparticles. ACS Nano, 2014, 8(5):4334-47.
7. Luo Haiming*, Lu Lisen, Liu Ni, Li Qingqing, Yang Xiaoquan, Zhang Zhihong*. Curcumin loaded sub-30 nm targeting therapeutic lipid nanoparticles for synergistically blocking nasopharyngeal cancer growth and metastasis. Journal of Nanobiotechnology. 2021, 19(1):224.
8. Luo Haiming, England G Christopher, Goel Shreya, Graves A Stephen, Ai Fanrong, Liu Bai, Theuer P Charles, Wong C Hing, Nickles J Robert, Cai Weibo. ImmunoPET and Near-Infrared Fluorescence Imaging of Pancreatic Cancer with a Dual-Labeled Bispecific Antibody Fragment. Molecular Pharmaceutics, 2017, 14(5):1646-1655.
9. Luo Haiming#, Shi Jiyun#, Jin Honglin, Fan Di, Lu Lisen, Wang Fan, Zhang Zhihong. An (125)I-labeled octavalent peptide fluorescent nanoprobe for tumor-homing imaging in vivo. Biomaterials, 2012, 33(19):4842-50.
10. Luo Haiming, Yang Jie, Jin Honglin, Huang Chuan, Fu Jianwei, Yang Fei, Gong Hui, Zeng Shaoqun, Luo Qingming, Zhang Zhihong. Tetrameric Far-Red Fluorescent Protein as a Scaffold to Assemble an Octavalent Peptide Nanoprobe for Enhanced Tumor Targeting and Intracellular Uptake In Vivo. The FASEB Journal, 2011, 25(6):1865-1873.
授權發明專利
1、駱海明；張立定；用于檢測人澱粉樣蛋白-β雙抗夾心ELISA檢測試劑盒；20220329，中國，專利号：202011227418.8
2、駱海明；駱清銘；張立定；用于檢測人澱粉樣蛋白-β的膠體金免疫層析試紙及其制備；20220325，中國，專利号：202110067679.6
3、駱海明；劉妮；胡順；曹凱；一種用于清除β-澱粉樣蛋白的特異性捕獲載體及其應用；20220520，中國，專利号：ZL202110345476.9
4、駱海明；張立定；分泌人澱粉樣蛋白-β單克隆抗體的雜交瘤細胞株及其應用；20230505，中國，專利号：ZL202011227808.5
5、駱海明；張立定；分泌抗絲氨酸磷酸化tau蛋白單克隆抗體的雜交瘤細胞株；20221014，中國，專利号：ZL202110067436.2
6、駱海明；劉妮；胡順；曹凱；楊昌文；納米材料用于制備鼻腔納米制劑腦靶向遞送腸道藥物應用；20220916，中國，專利号：ZL202110718344.6
7、駱海明；張立定；李豔青；牛是琦；一種用于阿爾茨海默病診療一體化的多功能的納米粒子；20230526，中國，專利号：ZL202110518125.3
學術兼職
擔任中國研究型醫院學會神經再生與修複專業委員會常務委員及阿爾茲海默病與生物标志物學組組長（202404-202903）、中國光學學會第四屆生物醫學光子學專業委員會常務委員（202411-202910）、白求恩精神研究會醫學人文分會第二屆理事會常務理事（202411-202910）、第三屆生物醫學工程學會生物醫學光子學分會青年委員。擔任Scientific Reports（2024年6月至今）、Experimental and Therapeutic Medicine（2022至今）期刊編委。以客座編輯在Biosensor、Frontiers in Cellular Neuroscience、Journal of Bio-X Research期刊各主辦特刊1期。
招生需求
招收生物、醫學、生物醫學工程及相關專業的碩士生和博士生3-4人，博士後人和預聘教師。
聯系方式：hemluo@hainanu.edu.cn
