張曉東 (Ph.D.)，中國科學院武漢物理與數學研究所磁共振專業博士畢業，原埃默裡大學國家靈長類動物研究中心副教授和影像中心副主任。多年來主要從事磁共振成像技術在非人靈長類動物模型的研究與應用，在神經影像學領域積累了豐富的科研經驗。曾在明尼蘇達大學磁共振研究中心（CMRR）、埃默裡大學（和佐治亞理工合辦）的生物醫學工程系，埃默裡國家靈長類動物研究中心等頂尖科研機構工作多年。深耕神經退行性疾病的影像學标志物開發，尤其在亨廷頓病（HD），中風（Stroke），記憶，HIV等猕猴模型的研究上取得了系列重要進展。當前的研究重點包括通過當代高場和超高場MRI影像技術的開發與優化（如彌散張量成像(DTI)、灌注MRI、靜息态功能MRI等）來揭示神經疾病的病理機制，并探索其早期診斷的影像學标志。

  研究方向：

1、開發和應用多模态MRI影像技術，包括彌散張量成像（DTI）、灌注MRI和靜息态功能MRI（rsfMRI），用于分析神經退行性疾病模型中的大腦微結構和功能網絡的變化。特别是應用于中風、阿爾茨海默病、亨廷頓病，帕金森病等神經退化疾病的病理研究和早期診斷。

2、結合機器學習和大數據分析技術，通過并行成像、多帶激發和壓縮感知等方法，優化非人靈長類腦部纖維通路和功能連接的影像檢測，提高影像數據質量，以支持神經影像學在腦疾病模型研究中的深入應用。

  學術論文（selected from about 100 journal publications）：

1.Yanev P, Martin-Jimenez C, Vesga-Jimenez DJ, Zvinys L, Weinrich N, Cree MA, Preuss TM, Zhang X, Yepes M*. Plasminogen activator inhibitor-1 mediates cerebral ischemia-induced astrocytic reactivity， J Cereb Blood Flow Metab. 2024 Aug 7. PMID: 39113414

2.C Li, F Tong, D Kempf, L Howell, X Zhang* Longitudinal evaluation of the functional connectivity changes in the secondary, somatosensory cortex (S2) of the monkey brain during acute stroke, Curr Res Neurobiol. 2023 Jun 23;5:100097. doi: 10.1016/j.crneur.2023.100097. eCollection 2023.PMID: 37404949

3.Y Meng, CX Li, X Zhang* Quantitative Evaluation of Oxygen Extraction Fraction Changes in the Monkey Brain During Acute Stroke by Using Quantitative Susceptibility Mapping, life, 2023, 13(4), 1008. PMID:37109537

4. C Li, D Kempf, L Howell, X Zhang* Effects of alfaxalone on cerebral blood flow and intrinsic neural activity of the rhesus

monkey: a comparison study with ketamine, Magn Reson Imaging, 2021 Jan; 75:134-

140 PMID: 33127411

5. Chun-Xia Li, Zhi-Hao Li, Xiaoping Hu, Xiaodong Zhang*, Jocelyne Bachevalier* Altered hippocampal-prefrontal Functional Network Integrity in Adult Macaque Monkeys with Neonatal Hippocampal Lesion, Neuroimage. 2020,227:117645. PMID: 33338613

6. Xiaodong Zhang*, Chun-Xia Li, Yumei Yan, Govind Nair, James K. Rilling, James G Herndon, Todd M. Preuss, Xiaoping Hu, Longchuan Li in-vivo diffusion MRI protocol optimization for the chimpanzee brain and examination of aging effects on the primate optic nerve at 3T, Magn Reson Imaging. 2020 Dec 22:S0730-725X(20)30669-X. PMID: 33359631

7. C Li, S Patel, X Zhang* Evaluation of multi-shell diffusion MRI acquisition strategy on quantitative analysis using multi-compartment models, Quant Imaging Med Surg, 2020 10(4):824-834 PMID: 32355646

8. Chun-Xia Li, Doty Kempf, Frank Tong, Yumei Yan, Zhengfeng Xu, Fawn Connor Stroud, Byron Ford, Leonard Howell, Xiaodong Zhang* Longitudinal MRI evaluation of ischemic stroke in basal ganglia of a macaque monkey with seizure, 2018, Comparative Medicine, 68(60:496-502 PMID:30486918

9. Yuguang Meng, Xiaoping Hu, Xiaodong Zhang*, Jocelyne Bachevalier* Diffusion Tensor Imaging Reveals Microstructural Alterations in Corpus Callosum and Associated Transcallosal Fiber Tracts in Adult Macaques with Neonatal Hippocampal Lesions, 2018, Hippocampus, 28(11):833-845 PMID:29978933

10. Silun Wang, Yonggang Li, Ramesh Paudyal, Byron Ford*, Xiaodong Zhang* Evaluation of Neuregulin-1's neuroprotection against ischemic injury in rats using diffusion tensor imaging, 2018, Magnetic Resonance Imaging, 53:63-70 PMID:30021123

11. Yuguang Meng, Jie Jiang, Jocelyne Bachevalier*, Xiaodong Zhang*, Anthony Chan* Developmental Whole Brain White Matter Alterations in Transgenic Huntington’s Disease Monkey, 2017, Scientific Reports 23;7(1):379. doi: 0.1038/s41598-017-00381-8. PMID: 28336929

12. E. Heuer, J. Jacobs, R. Du, S. Wang, O. P. Kiefer Jr., A. F. Cintron, J. Dooyema, Y. Meng, X. Zhang and L. C. Walker Cerebral Amyloid-Related Imaging Abnormalities (ARIA) in a Nonhuman Primate, J Alzheimers Dis. 2017;57(2):519-530. doi: 10.3233/JAD-160981. PMID: 28269776

13. Chunxia Li, Xiaodong Zhang* Effects of long duration administration of 1% isoflurane on resting cerebral blood flow and default mode network in macaque monkeys, Brain Connect. 2017 Mar;7(2):98-105. doi: 10.1089/brain.2016.0445. PMID: 28030956

14.Yundi Shi, Francois Budin, Eva Yapuncich, Ashley Rumple, Jeffrey Todd Young, Christa Payne, Xiaodong Zhang, Xiaoping Philip Hu, Jodi Godfrey, Brittany Howell, Mar M Sanchez, Martin Andreas Styner UNC-Emory infant atlases for macaque brain image analysis: postnatal brain development through 12 months, Front Neurosci. 2017;10:617. eCollection. PMID: 28119564

15.Xiaodong Zhang*, Chun-Xia Li Arterial Spin Labeling perfusion MRI of non-human primates, Quant Imaging Med Surg, 2016 Oct;6(5):573-581. PMID: 27942478

16.Yuguang Meng, Xiaoping Hu, Jocelyne Bachevalier*, Xiaodong Zhang* Decreased Functional Connectivity in Dorsolateral Prefrontal Cortical Networks in Adult Macaques with Neonatal Hippocampal Lesions: Relations to Visual Working Memory Deficits, Neurobiology of Learning and Memory, 2016 Oct;134 Pt A:31-7. PMID: 27063864

17. Silun Wang, Yonggang Li, Ramesh Paudyal, Byron D. Ford*, Xiaodong Zhang* Spatio-temporal assessment of the neuroprotective effects of neuregulin-1 on ischemic stroke lesions using MRI, Journal of the Neurological Sciences, 2015, 357:28-34. PMID:26183085

18. Frank Tong, Xiaodong Zhang, Doty Kempf, Manuel Yepes, Fawn Stroud, Stuart Zola, Leonard Howell An enhanced model of middle cerebral artery occlusion in nonhuman primates using an endovascular trapping technique 2015, AJNR Am J Neuroradiol 36(12):2354-9. PMIDL:26381560

19. Anthony W.S.* Chan, Jie Jiang, Yiju Chen, Chunxia Li, Yijuan Hu, Tim Chi, Sean Moran, Tayeb Rahim, Shihua Li, Xiaojiang Li, Stuart M. Zola, Claudia Testa, Hui Mao, Yoland Smith, Xiaodong Zhang and Jocelyne Bachevalier Progressive cognitive deficit, motor impairment and neural anatomical changes in Huntington’s disease monkeys,2015, PLOS one, 10(5):e0122335. PMID:25966278

20. Xiaodong Zhang*, Frank Tong, Chun-Xia Li, Yumei Yan, Govind Nair, Silun Wang, Doty Kempf, E Christopher Muly, Stuart Zola, Leonard Howell Temporal evolution of ischemic lesions in nonhuman primates: a diffusion and perfusion MRI study, PLOS one, 2015 Feb 6;10(2):e0117290. PMID:25659092

21. Yuguang Meng and Xiaodong Zhang* Transcallosal Connectivity Changes from Infancy to Late Adulthood: An Ex-vivo Diffusion Spectrum Imaging Study of Macaque Brains, Brain Connectivity, 2015, 5(3):147-55. PMID:25389564

22. Chun-Xia Li, James G Herndon, Francis J Novembre, Xiaodong Zhang* A longitudinal magnetization transfer imaging evaluation of brain injury in a macaque model of neuroAIDS, AIDS Research and Human Retroviruses, 2015,31(3):335-41. PMID:25376011

23. Chun-Xia Li, Xiaodong Zhang*, Amelia Komery, Yingxia Li, Hui Mao, James G Herndon, Francis J Novembre Longitudinal cerebral metabolic changes in pig-tailed macaques infected with the neurovirulent virus SIVsmmFGb, Journal of NeuroVirology, 2014, 20(6):612-9. PMID: 25377443

24. Yuguang Meng, Christa Payne, Longchuan Li, Xiaoping Hu, Xiaodong Zhang*, Jocelyne Bachevalier* Alterations of Hippocampal Projections in Adult Macaques with Neonatal Hippocampal Lesions: A Diffusion Tensor Imaging Study, 2014, Neuroimage, 102:828-837 PMID:25204865

25. In K Cho, Sean P Moran, Ramesh Paudyal, Karolina Piotrowska-Nitsche, Pei-Hsun Cheng, Xiaodong Zhang, Hui Mao and Anthony W.S. Chan* Longitudinal monitoring of stem cell graft in vivo with magnetic resonance imaging using MagA as a genetic reporter, Theranostics, 2014 Jul 27;4(10):972-89, PMID:25161700

26. Yuguang Meng, Xiaodong Zhang* In Vivo Diffusion Spectrum Imaging of Non-human Primate Brain: Initial Experience in Transcallosal Fiber Examination, Quant Imaging Med Surg, 2014, 4(2):129-35. PMID:24834425

27. Chan AW*, Xu Y, Jiang J, Rahim T, Zhao D, Kocerha J, Chi T, Moran S, Engelhardt H, Larkin K, Neumann A, Cheng H, Li C, Nelson K, Banta H, Zola SM, Villinger F, Yang J, Testa CM, Mao H, Zhang X, Bachevalier J A two years longitudinal study of a transgenic Huntington disease monkey. BMC Neurosci. 2014 Mar 3;15:36. PMID:24581271

28. Yan Y, Nair G, Li L, Patel S, Wilson M, Hu X, Sanchez M, Zhang X* In vivo evaluation of optic nerve development in non-human primates by using diffusion tensor imaging, Int J Dev Neurosci. 2014; 32:64-8. PMID:23831120

29. Howell BR, Godfrey J, Gutman DA, Michopoulos V, Zhang X, Nair G, Hu X, Wilson ME, Sanchez MM Social Subordination Stress and Serotonin Transporter Polymorphisms: Associations With Brain White Matter Tract Integrity and Behavior in Juvenile Female Macaques, Cereb Cortex., 2014, 24(12):3334-49. PMID:2487650

30. C Li, S Patel, E Auerbach, X Zhang* Dose-dependent effect of isoflurane on regional cerebral blood flow in anesthetized macaque monkeys, Neurosci Lett. 2013 Apr 29;541:58-62. PMID:23428509

31. C. Li; X. Zhang*, A Komery; Y Li; FJ Novembre; JG Herndon Longitudinal diffusion tensor imaging and perfusion MRI investigation in a macaque model of neuro-AIDS: A preliminary study, Neoroimage, 2011, PMID:21658455

32. L. Li, TM Preuss, JK Rilling, WD Hopkins, MF Glasser, B Kumar, R Nana, X Zhang, X Hu* Chimpanzee precentral corticospinal system asymmetry and handedness: A diffusion magnetic resonance imaging study, PLOS one, 5(9), e12886(2010) PMID: 20877630

33. Zhang X, Nagaoka T, Auerbach EJ, Champion R, Zhou L, Hu X, Duong TQ. Quantitative basal CBF and CBF fMRI of rhesus monkeys using three-coil continuous arterial spin labeling. Neuroimage. 2007 Feb 1;34(3):1074-83. doi: 10.1016/j.neuroimage.2006.10.011. Epub 2006 Nov 27.PMID: 17126036

34. Ayyagari AL, Zhang X, Ghaghada KB, Annapragada A, Hu X, Bellamkonda RV.Long-circulating liposomal contrast agents for magnetic resonance imaging. Magn Reson Med. 2006 May;55(5):1023-9. doi:10.1002/mrm.20846.PMID: 16586449

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