周欣，365英国上市官网在线客座教授，中國科學院精密測量科學與技術創新研究院研究員，博導，院長。基金委創新研究群體項目負責人，國家傑出科學青年基金、國家重大科研儀器設備研制專項（部委推薦）和國家重點研發計劃首席科學家。現任國家自然科學基金委員會醫學科學部第六屆專家咨詢委員會委員，國際華人醫學磁共振學會主席，中國化學會理事，中國生物物理學會分子影像學專委會副主任委員。獲2023年度國家技術發明獎二等獎（第一完成人）、湖北省科技獎一等獎（2次）、全國創新争先獎、首屆科學探索獎、CCTV 2018年度全國十大科技創新人物、“王天眷波譜學獎”等榮譽。
主要從事醫學影像與生物醫學工程的新儀器、新技術及新應用研究，在我國率先開展多核（多種原子核）磁共振成像（MRI）臨床研究。自主研制的創新醫療器械--人體肺部多核磁共振成像裝備獲國家藥品監督管理局批準上市，是當前全球首台獲批的可用于氣體成像的臨床多核磁共振成像裝備。成功“點亮”肺部，解決傳統MRI對肺部空腔無法清晰成像的難題，在全國多家三甲醫院開展了慢阻肺、腫瘤、新冠肺炎等肺部重大疾病的臨床應用。發展了多核和人工智能的MRI新技術，為肺部和腦部等重大疾病和腫瘤的早期檢測提供新的醫學影像手段與策略。發表SCI論文180餘篇，授權國内外發明專利110餘件。
招生需求：
招收物理、化學、生物醫學工程及相關專業的碩士生和博士生2-3人，博士後2人。
聯系方式：xinzhou@wipm.ac.cn
榮譽與獎勵：
2023 國家技術發明獎二等獎
2023 朱良漪分析儀器創新成果獎
2021 中國科學院年度創新人物
2020 全國創新争先獎
2019 首屆科學探索獎
2019 “國家高層次人才特殊支持計劃”科技創新人才
2018 CCTV 2018年度全國十大科技創新人物
2016 中國科學院青年科學家獎
代表性論著：
1 Haidong Li#, Xiuchao Zhao#, Yujin Wang#, Xin Lou#, Shizhen Chen, He Deng, Lei Shi, Junshuai Xie, Dazhong Tang, Jianping Zhao, Louis-S. Bouchard, Liming Xia*, Xin Zhou*. Damaged Lung Gas Exchange Function of Discharged COVID-19 Patients Detected by Hyperpolarized 129Xe MRI. Science Advances, Vol 7(1), eabc8180. (2021).
2 Yuan Fang#, Haidong Li#, Luyang Shen, Ming Zhang, Ming Luo, Hongchuang Li, Qiuchen Rao, Qi Chen, Yecheng Li, Zimeng Li, Xiuchao Zhao, Lei Shi, Qian Zhou, Yeqing Han, Fumin Guo, Xin Zhou*. Rapid Pulmonary 129Xe Ventilation MRI of Discharged COVID-19 Patients with Zigzag Sampling. Magnetic Resonance in Medicine, Vol 92(3), 956-966. (2024).
3 Zimeng Li#, Sa Xiao#, Cheng Wang, Haidong Li, Xiuchao Zhao, Caohui Duan, Qian Zhou, Qiuchen Rao, Yuan Fang, Junshuai Xie, Lei Shi, Fumin Guo, Chaohui Ye, Xin Zhou*. Encoding Enhanced Complex CNN for Accurate and Highly Accelerated MRI. IEEE Transactions on Medical Imaging, Vol 43(5), 1828-1840. (2024).
4 Lei Zhang#, Maosong Qiu#, Ruifang Wang, Sha Li, Xiaoxun Liu, Qiuyi Xu, Long Xiao, Zhongxing Jiang, Xin Zhou*, Shizhen Chen*. Monitoring ROS Responsive Fe3O4-based Nanoparticle Mediated Ferroptosis&Immunotherapy via 129Xe MRI. Angewandte Chemie International Edition, e202403771. (2024).
5 Yuqi Yang#, Baolong Wang#, Xu Zhang, Hongchuang Li, Sen Yue, Yifan Zhang, Yunhuang Yang, Maili Liu, Chaohui Ye, Peng Huang*, Xin Zhou*. Activatable Graphene Quantum-Dot-Based Nanotransformers for Long-Period Tumor Imaging and Repeated Photodynamic Therapy. Advanced Materials, Vol 35(23), 2211337. (2023).
6 Qiao Yu#, Lei Zhang#, Mou Jiang, Long Xiao, Yunhui Xiang, Ruifang Wang, Zhaoqing Liu, Rui Zhou, Minghui Yang, Conggang Li, Maili Liu, Xin Zhou, Shizhen Chen*. An NIR Fluorescence Turn-on and MRI Bimodal Probe for Concurrent Real-time in Vivo Sensing and Labeling of β-Galactosidase. Angewandte Chemie International Edition, Vol 62(46), e202313137. (2023).
7 Shizhen Chen#, Long Xiao#, Yu Li, Maosong Qiu, Yaping Yuan, Rui Zhou, Conggang Li, Lei Zhang, Zhongxing Jiang, Maili Liu, Xin Zhou*. In Vivo Nitroreductase Imaging via Fluorescence and Chemical Shift Dependent 19F NMR. Angewandte Chemie International Edition, Vol 61(50), e202213495.(2022).
8 Cheng Wang#, Lu Huang#, Sa Xiao#, Zimeng Li, Chaohui Ye, Liming Xia*, Xin Zhou*. Early Prediction of Lung Lesion Progression in COVID-19 Patients with Extended CT Ventilation Imaging. European Journal of Nuclear Medicine and Molecular Imaging, Vol 48, 4339-4349. (2021).
9 Qingbin Zeng#, Binglin Bie#, Qianni Guo*, Yaping Yuan, Qi Han, Xiaocang Han, Mingwei Chen, Xu Zhang, Yunhuang Yang, Maili Liu, Pan Liu, Hexiang Deng*, Xin Zhou*. Hyperpolarized Xe NMR Signal Advancement by Metal-Organic Framework Entrapment in Aqueous Solution. PNAS, Vol 117(30), 17558-17563. (2020).
10 Ming Zhang#, Haidong Li#, Yi Xiao#, Hongchuang Li, Xiaoling Liu, Xiuchao Zhao, Yu Zheng, Yeqing Han, Fumin Guo, Xianping Sun, Jianping Zhao, Shiyuan Liu*, Xin Zhou*. Assessment of Global and Regional Lung Compliance in Pulmonary Fibrosis With Hyperpolarized Gas MRI. Journal of Magnetic Resonance Imaging. (2024). DOI: 10.1002/jmri.29497.
11 Qiuchen Rao#, Haidong Li#, Qian Zhou#, Ming Zhang, Xiuchao Zhao, Lei Shi, Junshuai Xie, Li Fan, Yeqing Han, Fumin Guo, Shiyuan Liu, Xin Zhou*. Assessment of Pulmonary Physiological Changes Caused by Aging, Cigarette Smoking, and COPD with Hyperpolarized 129Xe Magnetic Resonance. European Radiology. (2024). DOI: 10.1007/s00330-024-10800-w.
12 Ming Zhang#, Haidong Li#, Hongchuang Li, Xiuchao Zhao, Xiaoling Liu, Yeqing Han, Xianping Sun, Chaohui Ye, Xin Zhou*. Dynamic Evaluation of Acute Lung Injury Using Hyperpolarized 129Xe Magnetic Resonance. NMR in Biomedicine, Vol 37(4), e5078. (2024).
13 Zimeng Li#, Sa Xiao#, Cheng Wang, Haidong Li, Xiuchao Zhao, Qian Zhou, Qiuchen Rao, Yuan Fang, Junshuai Xie, Lei Shi, Chaohui Ye, Xin Zhou*. Complementation-Reinforced Network for Integrated Reconstruction and Segmentation of Pulmonary Gas MRI with High Acceleration. Medical Physics, Vol 51(1), 378-393. (2024).
14 Shizhen Chen#, Lei Zhang#, Sha Li, Yaping Yuan, Bin Jiang, Zhongxing Jiang, Xu Zhang, Xin Zhou*, Maili Liu*. Detecting Biomarkers by Dynamic Nuclear Polarization Enhanced Magnetic Resonance. National Science Review. (2024). DOI: 10.1093/nsr/nwae228.
15 Long Xiao#, Lei Zhang#, Sha Li, Yue Zhu, Qiao Yu, Zhaoqing Liu, Maosong Qiu, Yu Li, Shizhen Chen*, Xin Zhou*. Visualization and Quantification of Drug Release by GSH-Responsive Multimodal Integrated Micelles. JACS Au, Vol 4(3), 1194-1206. (2024).
16 Chenlu Yuan#, Qianni Guo*#, Qingbin Zeng, Yaping Yuan, Weiping Jiang, Yuqi Yang, Louis-S. Bouchard, Chaohui Ye, Xin Zhou*. Dual-Signal Chemical Exchange Saturation Transfer (Dusi-CEST): An Efficient Strategy for Visualizing Drug Delivery Monitoring in Living Cells. Analytical Chemistry, Vol 96(4), 1436-1443. (2024).
17 Xu Zhang#, Yuqi Yang#, Yaping Yuan, Sen Yue, Xiuchao Zhao, Quer Yue, Qingbin Zeng, Qianni Guo, Xin Zhou*. Hyperpolarized 129Xe Atoms Sense the Presence of Drug Molecules in Nanohosts Revealed by Magnetic Resonance Imaging. Analytical Chemistry. (2024).
18 Qian Zhou#, Haidong Li#, Qiuchen Rao#, Ming Zhang, Xiuchao Zhao, Luyang Shen, Yuan Fang, Hongchuang Li, Xiaoling Liu, Sa Xiao, Lei Shi, Yeqing Han, Chaohui Ye, Xin Zhou*. Assessment of Pulmonary Morphometry using Hyperpolarized 129Xe Diffusion-Weighted MRI with Variable-Sampling-Ratio Compressed Sensing Patterns. Medical Physics, Vol 50(2), 867-878. (2023).
19 Ruifang Wang#, Maosong Qiu#, Lei Zhang#, Meiju Sui, Long Xiao, Qiao Yu, Chaohui Ye, Shizhen Chen*, Xin Zhou*. Augmenting Immunotherapy via Bioinspired MOF-based Ros Homeostasis Disruptor with Nanozyme-Cascade Reaction. Advanced Materials, Vol 35(49), 2306748. (2023).
20 Haiwei Shan, Lei Shi, Shuang Liu, Yaping Yuan, Hongchuang Li, Shizhen Chen, Xin Zhou*. A Local-Saturation-and-Delay MRI Method for Evaluation of Red Blood Cells Aggregation in Vivo for Tumor-Bearing or Drug-Used Rats. Frontiers in Bioengineering and Biotechnology, Vol 11, 1111840. (2023).
21 Cheng Wang#, Haidong Li#, Sa Xiao, Zimeng Li, Xiuchao Zhao, Junshuai Xie, Chaohui Ye, Liming Xia, Xin Lou, Xin Zhou*. Abnormal Dynamic Ventilation Function of COVID-19 Survivors Detected by Pulmonary Free-Breathing Proton MRI. European Radiology, Vol 32, 5297-5307 (2022).
22 Shizhen Chen#, Maosong Qiu#, Ruifang Wang, Lei Zhang, Conggang Li, Chaohui Ye, Xin Zhou*. Photoactivated Nanohybrid for Dual-Nuclei MR/US/PA Multimodal-Guided Photothermal Therapy. Bioconjugate Chemistry, Vol 33(9), 1729-1740. (2022).
23 Qian Zhou#, Qiuchen Rao#, Haidong Li, Ming Zhang, Xiuchao Zhao, Lei Shi, Chaohui Ye, Xin Zhou*. Evaluation of Injuries Caused by Coronavirus Disease 2019 Using Multi-Nuclei Magnetic Resonance Imaging. Magnetic Resonance Letters, Vol 1(1), 2-10. (2021).
24 Weiping Jiang#, Qianni Guo#, Qing Luo, Xiaoxiao Zhang, Yaping Yuan, Haidong Li, Xin Zhou*. Molecular Concentration Determination Using Long-Interval Chemical Exchange Inversion Transfer (CEIT) NMR Spectroscopy. The Journal of Physical Chemistry Letters, Vol 12, 8652-8657. (2021).
25 Yuqi Yang, Yingfeng Zhang, Baolong Wang, Qianni Guo, Yaping Yuan, Weiping Jiang, Lei Shi, Minghui Yang, Shizhen Chen, Xin Lou, Xin Zhou*. Coloring Ultrasensitive MRI with Tunable Metal-Organic Frameworks. Chemical Science, Vol 12(12), 4300-4308. (2021).
26 Ming Zhang#, Haidong Li#, Hongchuang Li, Xiuchao Zhao, Qian Zhou, Qiuchen Rao, Yeqing Han, Yina Lan, He Deng, Xianping Sun, Xin Lou, Chaohui Ye, Xin Zhou*. Quantitative Evaluation of Lung Injury Caused by PM2.5 Using Hyperpolarized Gas Magnetic Resonance. Magnetic Resonance in Medicine, Vol 84, 569-578. (2020).
27 Sa Xiao#, He Deng#, Caohui Duan, Junshuai Xie, Haidong Li, Xianping Sun, Chaohui Ye, Xin Zhou*. Highly and Adaptively Undersampling Pattern for Pulmonary Hyperpolarized 129Xe Dynamic MRI. IEEE Transactions on Medical Imaging, Vol 38(5), 1240-1250. (2019).
28 Yuqi Yang#, Shizhen Chen#, Haidong Li, Yaping Yuan, Zhiying Zhang, Junshuai Xie, Dennis.W Hwang, Aidong Zhang, Maili Liu, Xin Zhou*. Engineered Paramagnetic Graphene Quantum Dots with Enhanced Relaxivity for Tumor Imaging. Nano Letters, Vol 19(1), 441-448. (2019).
29 Haidong Li#, Zhiying Zhang#, Jianping Zhong, Weiwei Ruan, Yeqing Han, Xianping Sun, Chaohui Ye, Xin Zhou*. Oxygen-Dependent Hyperpolarized 129Xe Brain MR. NMR in Biomedicine, Vol 29(3), 220-225. (2016).
30 Haidong Li, Zhiying Zhang, Xiuchao Zhao, Xianping Sun, Chaohui Ye, Xin Zhou*. Quantitative Evaluation of Radiation-Induced Lung Injury with Hyperpolarized Xenon Magnetic Resonance. Magnetic Resonance in Medicine, Vol 76(2), 408-416. (2016).
31 李海東#，陳世桢#，婁昕，張定宇，周欣*. 多核磁共振成像助力新冠肺炎疫情防控. 中國科學基金，Vol 36(4), 644-653. (2022).
32 葉朝輝*，駱清銘*，周欣*. 影像揭示生命奧秘. 中國科學：生命科學，Vol 50(11), 1155-1157. (2020).
專利：
1. Xin Zhou; Yeqing Han; Xianping Sun; Lei Shi; Maili Liu; Chaohui Ye; Device Having Inert Gas Nucleus Channel and Method for Magnetic Resonance Imaging Using the Same, 2022-10-19, 歐洲, EP3422036B1.
2. Xin Zhou; Xianping Sun; Xiuchao Zhao; Maili Liu; Chaohui Ye; Optical-Fiber Atomic Light-Filtering Apparatus, 2020-10-6, 美國, US10795171B2.
3. 周欣；袁亞平；郭茜旎；孫獻平；葉朝輝；使用絕熱射頻脈沖測量射頻B1場分布的磁共振成像方法，2020-8-11，中國，ZL201911151143.1。
4. 周欣；謝軍帥；石磊；孫獻平；葉朝輝；一種基于降升頻的磁共振成像方法，2019-10-25，中國，ZL201810906189.9。
5. 周欣；肖灑；鄧鶴；孫獻平；葉朝輝；一種基于變采樣率的肺部超極化氣體動态成像方法，2018-12-25，中國，ZL201610743164.2。
主持科研項目：
1、 國家自然科學基金委員會，國家重大科研儀器研制項目（自由申請），82127802，腦部多核超靈敏MRI儀器研制，2022-01至2026-12，839萬元，在研，主持
2、 國家自然科學基金委員會，創新研究群體項目，21921004，生命波譜與成像，2020-01至2024-12，1050萬元，在研，主持
3、 科學技術部，國家重點研發計劃，2018YFA0704000，肺癌的超高靈敏譜學與成像新技術研究，2019-01至2024-08，2740萬元，在研，主持
4、 國家自然科學基金委員會，國家傑出青年科學基金，81625011，超靈敏磁共振成像，2017-01至2021-12，350萬元，已結題，主持
5、 國家自然科學基金委員會，國家重大科研儀器設備研制專項（部委推薦），81227902，用于人體肺部重大疾病研究的磁共振成像儀器系統研制，2013-01至2017-12，4400萬元，已結題，
