張立定，365英国上市官网在线博士後。2023年6月博士畢業于華中科技大學武漢光電國家研究中心，在駱海明教授的指導下從事阿爾茲海默病診斷與靶向治療方面的研究，獲生物醫學光子學博士學位。2023年7月進入海南大學生物學博士後流動站工作。
主要研究方向：
1） 阿爾茲海默病早期診斷
2） 阿爾茲海默病腦内相關病理蛋白的标記與成像
學術論文：
1. Liding Zhang#, Ying Su#, Xiaohan Liang, Kai Cao, Qingming Luo, Haiming Luo. Ultrasensitive and point-of-care detection of plasma biomarker in Alzheimer's disease using colorimetric and surface-enhanced Raman scattering dual-readout lateral flow assay. Nano Research. 2023; 16(5):7459-7469. (IF=9.9)
2. Liding Zhang, Kai Cao, Ying Su, Shun Hu, Xiaohan Liang, Qingming Luo, Haiming Luo. Colorimetric and surface-enhanced Raman scattering dual-mode magnetic immunosensor for ultrasensitive detection of blood phosphorylated tau in Alzheimer's disease. Biosensors and Bioelectronics. 2022; 222:114935. (IF=12.6)
3. Liding Zhang#, Xuewei Du#, Ying Su#, Shiqi Niu, Yanqing Li, Xiaohan Liang, Haiming Luo. Quantitative assessment of AD markers using naked eyes: point-of-care testing with paper-based lateral flow immunoassay. Journal of Nanobiotechnology. 2021; 19(1):366. (IF=10.2)
4. Liding Zhang, Changwen Yang, Yanqing Li, Shiqi Niu, Xiaohan Liang, Zhihong Zhang, Qingming Luo, Haiming Luo. Dynamic changes in the levels of amyloid-β42 species in the brain and periphery of APP/PS1 mice and their significance for Alzheimer’s disease. Frontiers In Molecular Neuroscience. 2021; 14:723317. (IF=4.8)
5. Wensheng Qu#, Liding Zhang#, Xiaohan Liang, Zhiyuan Yu, Hao Huang, Jing Zhao, Yinping Guo, Xirui Zhou, Shabei Xu, Haiming Luo, Xiang Luo. Elevated Plasma Oligomeric Amyloid β-42 is Associated with Cognitive Impairments in Cerebral Small Vessel Disease. Biosensors. 2023,13(1):110. (IF=5.4)
6. Liding Zhang#, Xuewei Du#, Zhixin Chen, Congjie Chen, Nanxin Gong, Yihao Song, Yuzhu Song, Qinqin Han, Xueshan Xia, Haiming Luo, Jinyang Zhang. Instrument-Free and Visual Detection of Salmonella Based on the Magnetic Nanoparticles and Antibody-Probe Immunosensor. International Journal of Molecular Sciences. 2019,20 (18):4645. (IF=5.6)
7. Liding Zhang#, Qiujiang Wei#, Qinqin Han, Qiang Chen, Wenlin Tai, Jinyang Zhang, Yuzhu Song, Xueshan Xia. Detection of Shigella in Milk and Clinical Samples by Magnetic Immunocaptured-Loop-Mediated Isothermal Amplification Assay. Frontiers in Microbiology. 2018,9:94. (IF=5.2)
8. Liding Zhang#, Xuewei Du#, Congjie Chen, Zhixin Chen, Li Zhang, Qinqin Han, Xueshan Xia, Yuzhu Song, Jinyang Zhang. Development and Characterization of Double-antibody Sandwich ELISA for Detection of Zika Virus Infection. Viruses. 2018,10(11): 634. (IF=4.7)
9. Liding Zhang, Yaoqiang Shi, Congjie Chen, Qinqin Han, Qiang Chen, Xueshan Xia, Yuzhu Song, Jinyang Zhang. Rapid, Visual Detection of Klebsiella pneumoniae Using Magnetic Nanoparticles and a Horseradish Peroxidase-Probe Based Immunosensor. Journal of Biomedical Nanotechnology. 2019,15:1061-1071. (IF=2.9)
10. Liding Zhang, Xiaohan Liang, Zhihong Zhang, and Haiming Luo. Cerebrospinal fluid and blood biomarkers in the diagnostic assays of Alzheimer's disease. Journal of Innovative Optical Health Sciences. 2022; 15(1)223001. (IF=2.5)
11. Liding Zhang, Xuewei Du, Qiujiang Wei, Qinqin Han, Qiang Chen, Mi Zhang, Xueshan Xia, Yuzhu Song, Jinyang Zhang. Development and Application of an Immunocapture PCR Diagnostic Assay Based on the Monoclonal Antibody for the Detection of Shigella. Iranian Journal of Biotechnology. 2020,18(1): e2244. (IF=1.3)
12. Liding Zhang#, Xuewei Du#, Qian Chen, Qinqin Han, Qian Chen, Mi Zhang, Xueshan Xia, Yuzhu Song, Jinyang Zhang. Development of a rapid, one-step-visual method to detect Salmonella based on immunocapture-Loop Mediated Isothermal Amplification. Iranian Journal of Veterinary Research. 2020,21(1): 20-25. (IF=1.2)
專利：
1. 張金陽，張立定。肺炎克雷伯杆菌的IC-PCR檢測引物組及其應用。專利号：ZL201811342422.1
2. 張金陽，張立定。用于檢測肺炎克雷伯杆菌的特異性抗體組及應用。專利号：ZL201810261060.7
3. 張金陽，張立定。一種單克隆抗體及其應用。專利号：ZL201811342423.6
4. 駱海明，張立定。分泌人澱粉樣蛋白-β單克隆抗體的雜交瘤細胞株及其應用。專利号：ZL202011227808.5。
5. 駱海明，張立定。用于檢測人澱粉樣蛋白-β雙抗夾心ELISA檢測試劑盒。專利号：ZL202011227418.8
6. 駱海明，駱清銘，張立定。一種用于檢測人澱粉樣蛋白-β的膠體金免疫層析試紙及其制備。專利号：ZL2021110067679.6
7. 駱海明，張立定。二種分泌抗絲氨酸磷酸化tau蛋白單克隆抗體的雜交瘤細胞株。專利号：ZL202110067436.2
8. 駱海明，張立定。一種用于阿爾茨海默病診療一體化的多功能的納米粒子。專利号：ZL202110518125.3
科研項目：
國家自然科學基金面上項目（81971025）：活化小膠質細胞的特異性标記及在阿爾茲海默症進展期間通過動态分子成像區分其表型的研究，2020.01-2023.12，參與。
獲獎與榮譽稱号：
第十五屆生物學和醫學光子學與成像國際會議PIBM“最佳學生論文獎”
2022年獲得華中科技大學武漢國家研究中心國光學子一等獎學金
2022年獲得華中科技大學華中科技大學三好研究生
2023年獲得華中科技大學博士優秀學業獎學金
