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23 2023.02

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    郭哲杉

郭哲杉(博士)。2019年博士畢業于浙江大學生物醫學工程專業;2019-2022年在明尼蘇達大學神經調控中心進行博士後研究;2022年4月就職于應脈醫療科技(上海)有限公司,任神經調控部高級科學家;2022年12月入職365英国上市官网在线。

  研究方向:

利用非人靈長類及大鼠疾病模型(帕金森病,癫痫,阿爾茨海默症等),通過在體電生理、影像學、計算機建模等手段,研究上述疾病的神經機制,并開發新型神經調控方法。研究領域涉及神經調控、腦機接口、腦電信号分析與處理等。

  學術論文:
1.  Guo Z, Feng Z*, Wang Y & Wei X. Simulation study of intermittent axonal block and desynchronization effect induced by high-frequency stimulation of electrical pulses[J]. Frontiers in Neuroscience, 2018, 12:858.

2.  Guo Z, Feng Z*, Yu Y, et al. Sinusoidal stimulation trains suppress epileptiform spikes induced by 4-AP in the rat hippocampal CA1 region in-vivo[C]. Conf Proc IEEE Eng Med Biol Soc, 2016, 2016:5817.

3.  Zheng L, Feng Z, Guo Z, Huang L. Simulation Study of Intermittent Responses of Neuronal Populations to Axonal High-Frequency Stimulation[C]. Conf Proc IEEE Eng Med Biol Soc, 2019: 3001-3004.

4.  Feng Z*, Guo Z, Wang Z. Advances in Understanding The Mechanisms of Deep Brain Stimulation[J]. Progress in Biochemistry and Biophysics, 2018, 45(12): 1197-1203.

5.  Cai Z, Feng Z*, Guo Z, Zhou W, Wang Z & Wei X. Novel stimulation paradigms with temporally-varying parameters to reduce synchronous activity at the onset of high frequency stimulation in rat hippocampus[J]. Frontiers in Neuroscience, 2017, 11:563.

6.  Feng Z*, Wang Z, Guo Z, Zhou W, Cai Z & Durand DM. High frequency stimulation of afferent fibers generates asynchronous firing in the downstream neurons in hippocampus through partial block of axonal conduction[J]. Brain Research, 2017, 1661:67.

7.  Yu Y, Feng Z*, Cao J, Guo Z, Wang Z, Hu N & Wei X. Modulation of local field potentials by high-frequency stimulation of afferent axons in the hippocampal CA1 region[J]. Journal of Integrative Neuroscience, 2016, 15(01):1-17.

8.  Wang Z, Feng Z*, Yu Y, Zhu Y & Guo Z. Detection of single unit spikes during orthodromic-high frequency stimulation in rat hippocampus[C]. Conf Proc IEEE Eng Med Biol Soc, 2016, 2016:5813.

9.  Feng Z*, Yu Y, Guo Z, Cao J & Durand DM. High frequency stimulation extends the refractory period and generates axonal block in the rat hippocampus[J]. Brain stimulation, 2014, 7(5): 680-689.

  主持和參與的部分科研項目:
1.  美國國立衛生研究院項目:“Neuronal Activity in MC and SMA during STN and GPi DBS in the Parkinsonian Monkey”(4R37NS077657-10),2012-2025,67萬美元(參與2019.5-2022.4)
2.  美國國立衛生研究院項目:“Basal Ganglia Cortical Coupling and Connectivity Changes in PD and DBS”( 5R01NS037019-23),1999-2023,220萬美元(參與2019.5-2022.4)
3.  國家自然科學基金面上項目:大腦深部電刺激的神經網絡作用機制研究(30970753),2010-2012,30萬人民币,參與

  授權專利:

多功能神經電刺激系統控制軟件 V1.0. 2015SR110707, 2015. (第二發明人)

聯系方式: guozheshan@hainanu.edu.cn